Alvin Carter Powers, M.D.
Office Address: Vanderbilt Diabetes Center, Room 8435 MRBIV
Vanderbilt University, Nashville, TN 37232-0202
Email: Al.powers@vanderbilt.edu
Office Phone Number: (615) 936-7678; Fax: (615) 936-0063
Date and Place of Birth: June 21, 1954; Memphis, TN
Education
:
1976 B.A. University of Virginia, Charlottesville, VA
1979 M.D. University of Tennessee Center for Health Sciences, Memphis, TN
Postdoctoral Training
:
Internship and Residencies
1979-80 Intern in Medicine, Duke University Medical Center, Durham, NC
1980-82 Resident in Medicine, Duke University Medical Center, Durham, NC
1981 Assistant Chief Resident in Medicine, Duke University Medical Center,
Durham, NC
Fellowships
1982-83 Research Fellow in Medicine, Joslin Diabetes Center, Boston, MA
1982-87 Research Fellow in Medicine, Harvard Medical School, Boston, MA
1983-87 Clinical and Research Fellow in Medicine, Massachusetts General
Hospital, Boston, MA
Licensure and Certification
:
1980 National Board of Medical Examiners, No. 224289
1981 North Carolina Board of Registration, No. 25402
1982 Massachusetts Board of Registration, No. 50054
1982- Diplomate, American Board of Internal Medicine, No. 087991
1986- Board Certification, Endocrinology and Metabolism, No. 087991
1982- Tennessee Board of Registration, No. MD0000018885
Academic Appointments
:
1987-88 Instructor in Medicine, Harvard Medical School, Boston, MA
1988-96 Assistant Professor of Medicine, Vanderbilt University School of
Medicine, Nashville, Tennessee
1991-95 Research Associate, VA Medical Center, Nashville, TN
1996-2004 Associate Professor of Medicine (with tenure), Vanderbilt University
School of Medicine, Nashville, Tennessee
1996- Director, Vanderbilt Short-Term Research Training in Diabetes,
Endocrinology, and Metabolism for medical students (NIH T35-DK07383)
1998-2004 Associate Professor, Department of Molecular Physiology and
Biophysics, Vanderbilt University School of Medicine, Nashville,
Tennessee
Alvin Carter Powers, MD, Curriculum Vitae - Page 2
2004- Professor of Medicine, Molecular Physiology and Biophysics,
Vanderbilt University School of Medicine, Nashville, Tennessee
2004-2007 Ruth K. Scoville Professor of Medicine, Molecular Physiology and
Biophysics, Vanderbilt University School of Medicine, Nashville,
Tennessee
2000-2005 Chief, Endocrinology and Diabetes Section, Nashville VA Medical Center,
Nashville, TN
2005- Director, Vanderbilt Diabetes Research and Training Center
2007- Director, Vanderbilt Diabetes Center
2007- Joe C. Davis Chair in Biologic Science, Vanderbilt University School of
Medicine, Nashville, Tennessee
2010- Chief, Division of Diabetes, Endocrinology, and Metabolism, Department
of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
Hospital Appointments
:
1984-1986 Member, Internal Medicine Associates, Massachusetts General Hospital
(Medical Evening Unit), Boston, MA
1985-88 Member, Thyroid Associates, Massachusetts General Hospital, Boston,
MA
1987-88 Clinical Assistant in Medicine, Massachusetts General Hospital, Boston,
MA
1988-96 Assistant Professor of Medicine, Vanderbilt University Medical Center,
Nashville, Tennessee
1989-97 Director, Vanderbilt Endocrinology Grand Rounds, Vanderbilt University
Medical Center, Nashville, Tennessee
1991-95 Research Associate, VA Medical Center, Nashville, TN
1995- Staff Physician, Tennessee Valley Health System, Nashville VA Medical
Center, Nashville, TN
1996-2004 Associate Professor of Medicine (with tenure), Vanderbilt University
Medical Center, Nashville, Tennessee
2004-2007 Ruth K. Scoville Professor of Medicine, Molecular Physiology and
Biophysics, Vanderbilt University School of Medicine, Nashville, TN
2000-2005 Chief, Endocrinology and Diabetes Section, Nashville VA Medical Center,
Nashville, TN
2007- Joe C. Davis Chair in Biologic Science, Vanderbilt University School of
Medicine, Nashville, Tennessee
2007- Director, Vanderbilt Diabetes Center
2010- Chief, Division of Diabetes, Endocrinology, and Metabolism, Department
of Medicine, Vanderbilt University School of Medicine, Nashville,
Tennessee
Professional Organizations
:
1984 Endocrine Society
1986 American Diabetes Association
1990 American Federation of Medical Research
1992 Juvenile Diabetes Research Foundation, Inc.
1996 Southern Society for Clinical Investigation
2006 European Association for the Study of Diabetes
2009 American Society for Biochemistry and Molecular Biology
Alvin Carter Powers, MD, Curriculum Vitae - Page 3
2013 Fellow, American College of Physicians
2017 Association of American Physicians
Professional Activities
:
Intramural:
1994-97 Chairman, Nashville Veterans Administration Hospital Credentials and
Clinical Privileges Committee
1995-2000 Medical Scientist Training Program (M.D./Ph.D.) Committee, Vanderbilt
University School of Medicine
1997-1998 Clinical Investigator Track Committee, Department of Medicine Residency
Program, Vanderbilt University School of Medicine
2000-2001 Research and Development Committee, Nashville VA
Medical Center, Nashville, TN
2002-2006 Member, Promotion Committee for Class of 2006, Vanderbilt University
School of Medicine
2002-2006 Member, Pilot and Feasibility Grant Review Committee, Vanderbilt
Diabetes Research and Training Center, Nashville, TN
2004-05 Member, Patient-Oriented Research Emphasis Committee as part of
curriculum planning for medical students, Vanderbilt University School of
Medicine
2004 Member, Intern Selection Committee, Department of Medicine, Vanderbilt
University School of Medicine
2005- Interviewer of applicants to Vanderbilt School of Medicine, Vanderbilt
Medical Scientist Training Program, Vanderbilt Interdepartmental
Graduate Program
2006- Executive Faculty, Vanderbilt University School of Medicine
2010- Executive Committee of Department of Medicine, Vanderbilt University
Medical Center
2011-2014 Faculty Senate, Vanderbilt University
2011-2012 Executive Committee of Executive Faculty, Vanderbilt University School
of Medicine
2011-2013 Member, LCME Site Visit Steering Committee, Vanderbilt University
School of Medicine; Chair, Educational Program – Structure – General
Design Subcommittee
2011-2012 Diabetes Thread Group Leader, Curriculum Revision Committee 2.0,
Vanderbilt University School of Medicine
2011-2012 Member, Cornelius Vanderbilt Scholarship Selection Committee
2012-2014 Member, Executive Admissions Committee, for Vanderbilt University
School of Medicine
2013 Member, ad hoc steering committee for Vanderbilt University School of
Medicine initiative in regenerative medicine
2015-2016 Executive Committee of Executive Faculty, Vanderbilt University School
of Medicine
Extramural:
1993- Reviewer for journals such as Diabetes, Molecular Endocrinology,
American Journal of Physiology, Journal of Clinical Investigation,
Diabetologia, Biochemistry, Endocrinology, Lancet, Journal of Clinical
Alvin Carter Powers, MD, Curriculum Vitae - Page 4
Endocrinology and Metabolism, Hormone and Metabolic Research,
Clinical Science, Nature Medicine, PNAS, American Journal of
Transplantation, Cell Metabolism
1994 Review Committee, National Institutes of Health, RFA DK 94-17,
“Diabetes Interdisciplinary Research Programs”
1995-2000 Member, Tennessee Diabetes Prevention and Control Program (State
Task force to reduce burden of diabetes in Tennessee)
1996-2001 Ancillary Studies Committee, Diabetes Prevention Trial-Type I (NIH trial
to prevent Type 1 diabetes)
1997 Review Committee, National Institutes of Health, “Diabetes
Interdisciplinary Research Programs”
1997 Review Committee for Diabetes Research Centers funded by Veterans
Administration/Juvenile Diabetes Foundation, Inc.
1997-2000 Annual Meeting Steering Committee, The Endocrine Society
1999-2000 Chair, Annual Meeting Steering Committee for 2000 meeting of The
Endocrine Society. Toronto, Ontario, Canada
2001-2006 Editorial Board, American Journal of Physiology: Endocrinology and
Metabolism
2002-2005 Chair, Meetings & Educational Program Committee, The Endocrine
Society
2002-2004 Member, International Task Force, The Endocrine Society
2002-2010 Member, Medical Science Review Committee, Juvenile Diabetes
Research Foundation, International, New York, NY
2002-2003 Member, NIH Study Section for Small Business Innovation Research and
Small Business Technology Transfer Research-Diabetes and
Endocrinology
2003 Review Committee, National Institutes of Health, Special Emphasis
Panels for Diabetes Interdisciplinary Program Projects
2003 Member, Review Committee for Pancreatic Islet Transplantation Centers,
Juvenile Diabetes Research Foundation, International, New York, NY
2003 Member, NIH Islet Transplantation Advisory Committee, Bethesda, MD
2004 Member, NIH Trans-Institute Angiogenic Research Program
Workshop, Towson, MD
2005 Co-Chair, Annual Meeting Steering Taskforce Committee of The
Endocrine Society.
2005-06 Ad hoc member, Cellular Aspects of Diabetes & Obesity Study Section
(CADO) Study Section, National Institutes of Health, June 2005, October
2005, February 2006
2005 Study Section, National Institutes of Health, RFA “Beta Cell Regeneration
for Diabetes Therapy”, November 2005
2005 Chair, Review Committee, National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel, Podiatry Summer
Research Fellowships
2006 Co-organizer, Keystone Symposium for 2006, “Pancreatic Islets: From
Development to Transplantation”
2006 Co-organizer for NIH Meeting in April 2006, “Imaging the Pancreatic Beta
Cell in Health and Disease,” Washington, D.C.
2006-2009 Chair, Steering Committee of Islet Cell Resource Centers of National
Center for Research Resources, National Institutes of Diabetes and
Digestive Kidney Diseases, Juvenile Diabetes Research Foundation
International
Alvin Carter Powers, MD, Curriculum Vitae - Page 5
2006-2010 Member, Cellular Aspects of Diabetes & Obesity Study Section (CADO)
Study Section, National Institutes of Health
2006 Member, Human Pancreas Development Committee of Juvenile Diabetes
Research Foundation International
2006-2010 Editorial Board, Journal of Clinical Endocrinology and Metabolism
2007-2009 Member, Executive Committee of NIH-funded Diabetes Centers
(DRTCs/DERCs)
2007-2008 Chair, Executive Committee of NIH-funded Diabetes Centers
(DRTCs/DERCs)
2008-2011 Elected Member of Council of The Endocrine Society (Board of Directors)
2009 Co-chair, Juvenile Diabetes Research Foundation Bioengineering RFA
Review Panel
2009 Grant reviewer, European Research Council of the European Commission
2009 Member, NIDDK committee to develop strategic plan for diabetes
research (member of beta cell subcommittee and infrastructure
subcommittee)
2009-2014 Member, Research Policy Committee, American Diabetes Association,
Alexandria, VA
2009-2011 Member, Beta Cell Therapies Research Portfolio Advisory Committee,
Juvenile Diabetes Research Foundation International, New York, NY
2009-2011 Member, Foundation for the NIH Biomarkers Consortium related to Beta
Cell Mass and Function
2010-2016 Co-editor, The Year in Diabetes and Obesity; published by Annals of the
New York Academy of Sciences. Founding co-editor with Rexford S.
Ahima, University of Pennsylvania
2010-2016 Member, Advisory Committee of Integrated Islet Distribution Program,
National Institutes of Diabetes and Digestive Kidney Diseases
2010-2011 Member, Finance Committee, American Diabetes Association, Alexandria,
VA
2010-2014 Member, Scientific Statements Taskforce/Committee, The Endocrine
Society
2010 Chair, Study Section to Review R24 grant, NIDDK
2010-2014 Editorial Board, Endocrinology
2011-2014 Member, Advocacy and Public Outreach Committee, The Endocrine
Society
2011-2014 Chair, Research Policy Committee, American Diabetes Association,
Alexandria, VA
2011 Member, Scientific Advisory Panel, Juvenile Diabetes Research
Foundation, International, New York, NY
2011-2013 Member, Planning Committee for Scientific Program, American Diabetes
Association, Alexandria, VA
2011 Corporate Chair, Annual fund-raising walk for Middle Tennessee Chapter
of Juvenile Diabetes Research Foundation, Nashville, TN
2011 Member, Juvenile Diabetes Research Foundation Bioengineering RFA
Review Panel
2011 Member, Juvenile Diabetes Research Foundation RFA Review Panel,
“Pathways and Targets for Beta Cell Regeneration”
2011 Co-chair, Organizing Committee, NIDDK Workshop, “Human Tissue for
Diabetes Complications Research,” Bethesda, MD
Alvin Carter Powers, MD, Curriculum Vitae - Page 6
2011- External advisor (intermittent, ad hoc) for NIH-funded diabetes research
centers or training grants (e.g., Yale, Columbia, Duke, Michigan,
University of Washington, Stanford, University of Colorado)
2011-2018 Member, Scientific Advisory Board, JDRF nPOD (Network for Pancreatic
Organ Donors with Diabetes)
2013-2014 Member, Executive Committee of NIDDK Beta Cell Biology Consortium
2013-2016 Member, Centennial Taskforce of The Endocrine Society
2013-2014 Member, International Strategy Task Force of The Endocrine Society
2013-2017 Member, Mentor Advisory Committee for “Pathways Program” of
American Diabetes Association
2014-2017 Member, National Board of Directors, American Diabetes Association
2014 Member, American Diabetes Association Governance, Business and
Mission Strategic Review Task Force
2014 Member, Next Generation Taskforce of The Endocrine Society
2014- Member, NIDDK Human Islet Research Network (HIRN) Trans Network
Committee
2014- Chair, Steering Committee, NIDDK Human Islet Research Network
(HIRN) Consortium on Targeting And Regeneration (CTAR)
2014- Member, Nashville Community Leadership Board, American Diabetes
Association, Middle Tennessee Chapter
2016 President-Elect, Medicine & Science, American Diabetes Association
2016 Co-organizer, Satellite Meeting of JDRF nPOD 8th Annual Scientific
Meeting, "Emerging Technologies to Study the Human Pancreas and
Islet: from the Whole Organ to a Single Cell," Miami, FL
2016 Advisory Group and Program Planning Committee, “Focus on Fellows,”
American Diabetes Association
2016-2019 Editorial Board, Journal of the Endocrine Society
2016 Member, Strategic Planning Committee, American Diabetes Association
2016 Co-Organizer, Advances in Research Conference, “Metabolic
Phenotyping: From Mouse to Man,” Satellite of annual meeting of
American Society of Nephrology
2017 President, Medicine & Science, American Diabetes Association
2017 Member, Marketing and Communication Task Force, American Diabetes
Association
2017 Co-chair, Organizing Committee, NIDDK Workshop, “The Interface of
Pancreatic Cancer with Diabetes, Obesity and Inflammation: Research
Gaps and Opportunities,” Bethesda, MD
2017-2018 Member, Insulin Affordability Working Group, American Diabetes
Association
2017 Member, CEO Search Committee, American Diabetes Association
2017- Chair, Steering Committee, NIDDK
Trans Network Steering Committee
for the Human Islet Research Network
2018 Co-chair, Heritage Council, American Diabetes Association
2018-2019 Member, Governance Task Force, The Endocrine Society
2018- Chair, Membership Advisory Group, American Diabetes Association
2019-2022 Member, Finance and Audit Committee, The Endocrine Society
2019 Chair, Study Section for Grants to Joint Canada-Israel Health Research
Program (JCIHRP)
Alvin Carter Powers, MD, Curriculum Vitae - Page 7
Awards and Honors:
1979 Alpha Omega Alpha
1979 Faculty Medal (Valedictorian), University of Tennessee Center for Health
Sciences
1979 Ciba Community Service Award
1979 Upjohn Achievement Award
1982 Haskell Schiff Award, Department of Medicine, Duke University Medical
Center
1995 Young Faculty Award, Southern Section of American Federation for
Clinical Research and Southern Society for Clinical Investigation
1996 Southern Society for Clinical Investigation
2000 Chair, Annual Meeting Steering Committee for 2000 meeting of The
Endocrine Society. Toronto, Ontario, Canada
2001-2019 Listed by Castle Connolly Medical Ltd, as one of ““America’s Top
Doctors”
2008-2011 Elected Member of Council of The Endocrine Society (Board of Directors)
2011 David Rumbough Award for Scientific Excellence, Juvenile Diabetes
Research Foundation International, New York, NY
2011 Charles Hollenberg Lectureship, Banting and Best Diabetes Centre,
University of Toronto, Toronto, Canada
2011 Kroc Lectureship, Division of Diabetes, Endocrinology & Metabolism,
Baylor College of Medicine, Houston, TX
2012 Ray A. and Robert L. Kroc Lectureship, Diabetes and Metabolism
Seminar Series, University of Washington, Seattle, WA
2013 Ray A. and Robert L. Kroc Lectureship in Diabetes and Endocrinology,
University of Alabama Birmingham, Birmingham, AL
2014-2016 Member, National Board of Directors, American Diabetes Association
2015 Ray A. and Robert L. Kroc Lecturer in Diabetes and Endocrinology,
Michigan Diabetes Research Center, University of Michigan, Ann Arbor,
MI
2016 President-Elect, Medicine & Science, American Diabetes Association
2016 Living and Giving Award, Tennessee Chapter of JDRF, Nashville, TN
2016 Elaine Sanders-Bush Award from the Vanderbilt University School of
Medicine for Mentoring Graduate and/or Medical Students in the
Research Setting
2017 President, Medicine & Science, American Diabetes Association
2017 Julio V. Santiago, M.D. Memorial Lecture, Department of Medicine,
Washington University, St. Louis, MO
2017 Election to Association of American Physicians
2017 James R. Givens Distinguished Visiting Professor and Medical Grounds,
Division of Endocrinology, Diabetes & Metabolism in the Department of
Medicine, University of Tennessee Health Sciences Center, Memphis, TN
2017 Banting Medal for Leadership and Service from the American Diabetes
Association
2017 Ray A. and Robert L. Kroc Lectureship in Diabetes and Endocrinology,
Stanford Diabetes Research Center, Stanford University, Paolo Alto, CA
2018 Harold Rifkin Lectureship in Diabetes and Endocrinology, Montefiore
Medical Center, Albert Einstein College of Medicine, New York, NY
2018 Kenneth Crispell Memorial Lectureship, University of Virginia Medical
Center, Charlottesville, VA
Alvin Carter Powers, MD, Curriculum Vitae - Page 8
2019 Fellow, American Association for the Advancement of Science (Elected)
2019 Kroc Lectureship, Division of Diabetes, Endocrinology & Metabolism and
Department of Medicine, Baylor College of Medicine, Houston, TX
Teaching Activities
:
1989-1997 Director, Vanderbilt Endocrinology Grand Rounds, Vanderbilt University
Medical Center, Nashville, Tennessee
1990-2008 Lecturer, Clinical Management Course for Fourth Year Vanderbilt Medical
Students, Vanderbilt University School of Medicine
1990- Lecturer, Diabetes Summer Student Research Program, Vanderbilt
University School of Medicine
1990 Lecturer, Ambulatory Care Elective for Internal Medicine Residents,
Vanderbilt University School of Medicine
1990-2005 Lecturer, Noon Seminar Series for Internal Medicine Residents,
Vanderbilt University School of Medicine
1991- Attending Physician, General Medical Service, Vanderbilt Internal
Medicine Residents, Nashville VA Medical Center
1991- Consulting Physician, Endocrine Consult Service, Vanderbilt University
and/or VA Medical Center, Nashville, TN
1993-2008 Lecturer, Pharmacology Course for Second Year Vanderbilt Medical
Students, Vanderbilt University School of Medicine
1993-2008 Lecturer, Biochemistry Course for First Year Vanderbilt Medical Students,
Vanderbilt University School of Medicine
1993-1998 Lecturer, Human Physiology Course for Senior Undergraduate Students,
Vanderbilt University
1994-2008 Lecturer, Physiology Course for First Year Vanderbilt Medical Students,
Vanderbilt University School of Medicine
1994 “Thyroid Disease and Ob/Gyn”, Vanderbilt Ob/Gyn Residents Lecture
Series, Vanderbilt University School of Medicine, Nashville, TN
1996 “PTH, Vitamin D, and Calcium Balance”, Renal Physiology for Nephrology
Fellows, Vanderbilt University Medical Center, Nashville, Tennessee
1996- Director, Vanderbilt Short-Term Research Training in Diabetes,
Endocrinology, and Metabolism for medical students (NIH T35-DK07383)
1996-2008 Small group leader, Physiology Course for First Year Vanderbilt Medical
Students, Vanderbilt University School of Medicine
1996- Thesis committee member for PhD candidates in Department of
Molecular Physiology and Biophysics and Department of Microbiology
and Immunology, Vanderbilt University School of Medicine and for PhD
and Masters candidates, School of Engineering, Vanderbilt University
2000-2002 Preceptor, Ecology of Health Care for First and Second Year Vanderbilt
Medical Students, Vanderbilt University School of Medicine
2002-2009 Clinical Endocrinology Update – Annual Board Review in Endocrinology
organized by The Endocrine Society, "Diabetes Mellitus"
2003-2005 Lecturer, Physiology Course for First Year Vanderbilt Graduate Students
(Interdepartmental Graduate Program), Vanderbilt University School of
Medicine
2004-2005 Patient-Oriented Research Emphasis Committee as part of curriculum
planning for medical students, Vanderbilt University School of Medicine
2004-2012 Mentor for medical student, Emphasis Program (part of curriculum for
medical students), Vanderbilt University School of Medicine
Alvin Carter Powers, MD, Curriculum Vitae - Page 9
2005-2010 Lecturer, Molecular Cell Biology & Genetics Course, Meharry Medical
School, Nashville, TN
2005-2008 Lecturer, Vanderbilt Center for Science Outreach, Virtual Scientist
Program
2007 Examiner/opponent for thesis defense of Daniel Nyqvist, “In vivo Imaging
of Islet Cells and Islet Revascularization, Rolf Luft Center for Diabetes
and Endocrinology, Karolinska Institutet
2007-2009 Small Group Leader, Molecular Foundations of Medicine Course
(required core as part of curriculum for Vanderbilt medical students)
2007- Lecturer, Molecular Physiology and Biophysics #333, “Molecular
Endocrinology of Obesity and Diabetes”
2008-2012 Lecturer, Molecular Foundations of Medicine Course for First-Year Vanderbilt
Medical Students, Vanderbilt University School of Medicine
2008-2012 Lecturer, Structure, Diabetes Intersession for First-Year Vanderbilt Medical
Students, Vanderbilt University School of Medicine
2008-2012 Lecturer, Structure, Function, and Development Course for First-Year Vanderbilt
Medical Students, Vanderbilt University School of Medicine
2008-2012 Lecturer, Disease, Diagnosis, and Therapeutics for Second-Year Vanderbilt
Medical Students, Vanderbilt University School of Medicine
2009- Organizer, NIDDK Medical Student Research Program in Diabetes – national
program where medical students conduct research during summer a NIH-
supported Diabetes Centers and then present their research at a symposium at
Vanderbilt University, Nashville, TN
2010 Examiner/opponent for thesis defense of Irene Hadjiyianni, University of Toronto
School of Graduate Studies
2015- Co-Director, Immersion in Diabetes Mellitus Course for 3
rd
and 4
th
year medical
students (Director, Michael Fowler, MD), Curriculum 2.0, Vanderbilt University
School of Medicine
Postdoctoral Fellows/Students
Trained:
1990-1992 Andreas Buchs, M.D., “Identification of Regions of GLUT 2 Responsible
for Transport Kinetics” (supported by fellowship award from NIH NRSA)
1990- Medical students in Vanderbilt Student Research Program in Diabetes
and Endocrinology (students during the summer between first and second
year of medical school): Shawn Gregory, Matthew Hindman, Karla Pou,
Amy McGaha, Cathi Spear, Chad Carr, Michael Blaha, Edward
McGillicudy, John Wilson, Mario Nieto. Brigham Au, Joshua Gilchrist,
Shannon Willis, Brian Coleman, Zubair Ahmed, Soorin Kim, Russell
Sundby, Michael Spinner, Derek Yee, Vincent de Chavez, Nicholas
Sutton, Kelsey Eitel, Scott Wisniewski, Gabriel Perez-Lopez, Aysha
Mushtaq, Yasir Bouchi, Kathryn Enriquez
1991-1993 Hiroshi Morita, M.D. “Co-expression of GLUT 2 and Glucokinase”
1992-1993 Noriko Ujihara, M.D. “Identification of GAD Autoantibody Heterogeneity”
1994 Andrea Hayes, M.D. “GAD Autoantibodies and IDDM”
1994-1998 Lan Wu, M.D. “Engineering of Glucose-regulated Hormone Secretion of
Neuroendocrine Cells” (supported by Juvenile Diabetes Foundation, Inc.
fellowship award)
1997-1999 Marcela Brissova, Ph.D. “Design of Immunoisolation Device for Islet
Transplantation” (supported by Juvenile Diabetes Foundation, Inc.
fellowship award)
Alvin Carter Powers, MD, Curriculum Vitae - Page 10
1997-1999 Wei Xu, M.D., “Diabetes Associated Insulin Secretory Defects”,
(supported by fellowship from Vanderbilt University Training Grant in
Endocrinology, Diabetes, and Metabolism)
2000-2001 Anita Chu, Brown University Medical Student, supported by Medical
Student Scholar Award from American Diabetes Association
2000-2003 Michael Fowler, M.D., postdoctoral fellow (clinical endocrinology fellow),
supported by Vanderbilt NIH training grant
2000- Undergraduate students working in our research laboratory – Adam
Travis, Suzanne Brown, Marybeth Jewel, Melissa Hodges, Reid Ravin,
Chalmers, Ridwan Rahman, Safwan Rahman, Nadia Ansari, Cramer
McCullen, Ian McGuinness, Kayela McLeod, Gerald Wakefield, Ariel
Helms, Zoya Khan, Alison Von Deylen, Ariella Saslafsky
2002- Rotating graduate students in Vanderbilt Interdepartmental Graduate
Program – Meredith Vaughn, Kylee Littlepage, Jeanelle Kantz, Qing Cai,
Rachael Reinert, Brandon Panero, Nora Kayton, Teagan Walter,
Jonathan Williams, Tammy Lundblad, Kristie Aamodt, Hannah Worschel,
Diane Saunders, Rachana Haliyur, Jack Walker, Joseph Elskar, Tiffany
Richardson, Jenna R Petronglo
2002-2003 Students in Vanderbilt Minority Summer Undergraduate Research
Program - Monica Giles, Isa Alexander
2002-2004 Mentor for Dr. Jeffrey Boord in his Career Development Award from the
Veterans Administration Research Service
2004-2006 Craig Hauck, Ph.D., postdoctoral fellow
2004-2007 Jeanelle Kantz, graduate student for Masters in Department of Molecular
Physiology and Biophysics
2005-2008 Medical students in Vanderbilt Medical Student Emphasis Program: Mario
Nieto, Brigham Au, Michael Spinner
2005-2009 Priyanka Brahmachary, Ph.D., postdoctoral fellow
2005-2012 Qing Cai, graduate student for Ph.D. in Department of Molecular
Physiology and Biophysics
2005-2012 John Virostko, graduate student for Ph.D. in Department of Biomedical
Engineering (co-mentor with Dr. Duco Jansen) and then postdoctoral
fellow in Vanderbilt University Institute of Imaging Science (co-mentor
with Dr. John Gore)
2006-2010 Lara Nyman, Ph.D., postdoctoral fellow; partially supported by American
Diabetes Association Mentor Award
2007-2012 Rachael Reinert, graduate student for Ph.D. in Department of Molecular
Physiology and Biophysics at Vanderbilt University School of Medicine;
Medical Scientist Training Program (MSTP) Student; supported by
individual grant, F30DK85932
2007-2010 Joseph Henske, M.D., postdoctoral fellow (clinical endocrinology fellow),
supported by NIH T32 training grant (T32DK07061)
2007-2008 Bart DeTaeye, Ph.D., postdoctoral fellow, partially supported by American
Diabetes Association Mentor Award
2009-2010 Ji-Young Hong, postdoctoral fellow
2009-2015 Nora Kayton, graduate student for Ph.D. in Department of Molecular
Physiology and Biophysics
2009-2011 Ioannis Papagiannis, M.D., postdoctoral fellow (clinical endocrinology
fellow)
2009-2014 Ana Robledo, M.D., postdoctoral fellow
2010-2011 Mahnaz Mellati, M.D., postdoctoral fellow
Alvin Carter Powers, MD, Curriculum Vitae - Page 11
2011-2015 Kristie Aamodt, graduate student for Ph.D. in Department of Molecular
Physiology and Biophysics at Vanderbilt University School of Medicine;
Medical Scientist Training Program (MSTP) Student; F30DK097921
2011-2017 Danielle Dean, Ph.D., postdoctoral fellow; supported by NIH training grant
(T320K07563) and JDRF postdoctoral fellowship grant
2011-2012 Alexandra Martin, M.D., postdoctoral fellow
2012-2017 Neil Phillips, Ph.D., postdoctoral fellow
2013-2014 Sapna Shah, M.D., postdoctoral fellow (clinical endocrinology fellow);
supported by NIH T-32 training grant (T32DK07061); received, but
declined Fogarty Fellowship
2013-2018 Nathaniel Hart, Ph.D., postdoctoral fellow
2013-2014 Dara Mize, M.D., postdoctoral fellow (clinical endocrinology fellow);
supported by NIH T-32 training grant (T32DK07061)
2014-2018 Diane Saunders, graduate student for Ph.D. in Department of Molecular
Physiology and Biophysics
2014-2018 Rachana Haliyur, graduate student for Ph.D. in Department of Molecular
Physiology and Biophysics at Vanderbilt University School of Medicine;
Medical Scientist Training Program (MSTP) Student; supported by
individual grant, F30DK112630
2015-2016 Asma Aljaberi, M.D., postdoctoral fellow
2016- John T. Walker, graduate student for Ph.D. in Department of Molecular
Physiology and Biophysics at Vanderbilt University School of Medicine;
Medical Scientist Training Program (MSTP) Student; supported by
individual grant, F30DK118830
2017-2018 Erick Spears, Ph.D., postdoctoral fellow
2018- Tiffany Richardson, graduate student for Ph.D. in Department of
Molecular Physiology and Biophysics; supported by NIH T-32 training
grant (T32DK07061); participant in Future Leaders Advancing Research
in Endocrinology (FLARE) of the Endocrine Society
2018- Diane Saunders, Ph.D., postdoctoral fellow
2018- Jordan Wright, M.D., Ph.D., postdoctoral fellow; (clinical endocrinology
fellow); supported by NIH T-32 training grant (T32DK07061)
2018- Heather Nelson, Ph.D., postdoctoral fellow
Alvin Carter Powers, MD, Curriculum Vitae - Page 12
Research Program:
Major Research Interests:
Pancreatic islet function, development, regeneration
Glucose-stimulated insulin secretion
Vascularization and innervation of pancreatic islets
Molecular pathogenesis of type 1 and type 2 diabetes
Pancreatic islet imaging in vivo
Clinical Interests:
Diabetes Mellitus
Thyroid Disease
General Endocrinology
Current Research Support
:
1. National Institutes of Health, “Diabetes Research and Training Center” (NIH
P60DK20593), Principal Investigator - Alvin C. Powers, 04/01/17 – 03/31/22.
2. Veterans Administration Merit Review Award, “Glucose and Lipid Effects on Human
Islets”, Principal Investigator - Alvin C. Powers, 04/01/15 – 09/30/19.
3. National Institutes of Health (NIDDK – Human Islet Research Network), “Molecular
Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas” (NIH
UC4DK104211), Principal Investigators – Alvin C. Powers, Seung Kim, Andrew Stewart
(Powers as contact PI), 09/30/14-06/30/19
4. National Institutes of Health, “Discovery of Pancreatic Signatures in Type 2 Diabetes
Mellitus”, (R24DK106755), Principal Investigator - Alvin C. Powers, 08/1/15 – 06/30/20.
5. National Institutes of Health, “Interrupting the Vicious Cycle of Obesity and Metabolic
Syndrome”, (R24DK090964), Principal Investigator - Alvin C. Powers (Jacob Friedman,
contact PI), 08/1/15 – 06/30/20.
6. National Institutes of Health (NIDDK – Human Islet Research Network), “High-resolution
analysis of juvenile human pancreas maturation” (NIH UC4
DK108120), Principal
Investigators – Christopher Wright, Alvin C. Powers, Richard Caprioli (Wright - contact PI),
10/1/2015 – 09/30/2020
7. National Institutes of Health (NIDDK – Human Islet Research Network), “Integrated
Program for Human Pancreas Procurement and Analysis”, (UC4 DK112232), Principal
Investigator - Alvin C. Powers,
Ali Naji, Contact PI 10/1/16 – 09/30/19.
8. National Institutes of Health, “Short-Term research training in diabetes, endocrinology, and
metabolism for medical students” (NIH T35-DK07383), Principal Investigator - Alvin C.
Powers, 05/01/13-04/30/18.
9. Juvenile Diabetes Research Foundation, “Quantitative MRI of the Pancreas in Type 1
Diabetes” Principal Investigator - Alvin C. Powers, 8/1/2015 – 7/31/2019.
10. Juvenile Diabetes Research Foundation, “Glucagon Receptor Antagonism in Beta Cell
Survival and Proliferation”, Principal Investigator – Alvin C. Powers (Co-PI with William
Holland at UTSW as contact PI), 2/1/2016 - 1/31/2020.
11. The Leona M. & Harry B. Helmsley Charitable Trust, “Human Atlas of the Neonatal
Development and Early Life Pancreas”, Principal Investigator – Alvin C. Powers (Co-PI
with Mark Atkinson as contact PI), 2/1/2017 – 1/31/2020
12. The Leona M. & Harry B. Helmsley Charitable Trust, “Improving isolation of pancreatic
islets in T1D to assess alpha cell function and gene expression”, Principal Investigator –
Alvin C. Powers, 11/1/2017 – 04/30/2019
Alvin Carter Powers, MD, Curriculum Vitae - Page 13
13. National Institutes of Health, “Molecular Mechanisms of Postnatal Islet Alpha-cell
Proliferation, (R01DK117147), Multi-PI R01 grant; Principal Investigator - Alvin C. Powers
(Wenbiao Chen, contact PI), 01/10/2019 – 12/31/2023
Past Research Support
:
1. American Diabetes Association Career Development Award, "Pancreatic Islet Specific
Gene Expression", Principal Investigator - Alvin C. Powers, 07/01/87 - 06/30/89.
2. National Institutes of Health (NIDDK R01 DK 43736-01), "Characterization of pancreatic
islet glucose transporter", Principal Investigator - Alvin C. Powers, 07/01/91 - 06/30/95.
3. Veterans Administration Career Development Research Associate Award,
"Characterization of beta cell glucose transporter", Principal Investigator - Alvin C. Powers,
07/01/91 - 06/30/95.
4. Veterans Administration Merit Review Award, ”Islet Autoantigens and Type I Diabetes”,
Principal Investigator - Alvin C. Powers, 10/01/93-09/30/96.
5. National Aeronautics and Space Administration Grant, "Encapsulation of Living Cells",
Principal Investigator - Taylor Wang; Co-Investigator - Alvin C. Powers, 02/01/93 -
01/31/97.
6. American Diabetes Association, “Regulation of Insulin Secretion in Non-islet Cells”,
Principal Investigator - Alvin C. Powers, 07/01/98-04/30/99.
7. Veterans Administration Merit Review Award, ”Diabetes-Associated Insulin Secretory
Defects”, Principal Investigator - Alvin C. Powers, 04/01/97-03/31/00.
8. Diabetes Prevention Trial-Type I (NIH/NIDDK/NIAID/ADA/JDF), Affiliate Center at
Vanderbilt University Medical Center, Clinical Director - Alvin C. Powers, 03/01/93-present.
9. Veteran Administration/JDF Diabetes Center Grant, “Metabolic Adaptations to Diabetes”,
Steve Davis, Principal Investigator; Role of Powers in Center: Principal Investigator,
Project #1, 01/01/97-12/31/01.
10. Veteran Administration/JDF Diabetes Center Grant, “Metabolic Adaptations to Diabetes”,
Steve Davis, Principal Investigator; Role of Powers in Center: Clinical Services Core,
Principal Investigator, 01/01/97-12/31/01.
11. Juvenile Diabetes Research Foundation International, “Optimization of PMCG capsules”,
Taylor Wang, Principal Investigator, Role of Powers in Project: Co-Investigator.
03/01/2001-02/28/2003
12. National Institutes of Health, “In Vivo Assessment of Transplanted Pancreatic Islets”
(supplemental Pilot and Feasibility Study to Vanderbilt Diabetes Research and Training
Center), Principal Investigator - Alvin C. Powers, 10/01/01-0/30/02.
13. National Institutes of Health, “Regulation of Insulin Secretion in Non-islet Cells” (NIH RO1-
DK55233), Principal Investigator - Alvin C. Powers, 05/01/99-04/30/04.
14. NASA, Immunoisolation of living islets as a functional cure for diabetes, Principal
Investigator – Taylor Wang, Co-investigator - Alvin C. Powers, 08/01/2002 - 10/01/2004
15. Veterans Administration Merit Review Award - ”Role of pdx-1 in Glucose-Stimulated
Insulin Secretion”, Principal Investigator - Alvin C. Powers, 10/01/00-09/30/04.
16. Juvenile Diabetes Research Foundation, “Endothelial Progenitor Cells and Islet
Transplantation”, Principal Investigator - Alvin C. Powers, 02/01/04-01/31/05.
17. National Institutes of Health, “Molecular determinants of vascularization in islets” (NIH
R21-DK63429), Principal Investigator - Alvin C. Powers, 09/30/02-07/31/05.
18. National Institutes of Health, “Gene transfer and revascularization of transplanted islets”
(NIH R21-DK62541), Principal Investigator - Alvin C. Powers, 08/01/02-07/31/06.
19. Juvenile Diabetes Research Foundation, “Tie-1 and Tie-2 Receptors in Islet
Revascularization.“ Principal Investigator - Alvin C. Powers, 01/01/05 – 12/31/06.
Alvin Carter Powers, MD, Curriculum Vitae - Page 14
20. Juvenile Diabetes Research Foundation, “Noninvasive assessment of pancreatic islet
mass” (1-2003-170), Principal Investigator - Alvin C. Powers, 02/01/03-01/31/07.
21. National Institutes of Health, “Pdx-1 and Maf Proteins in Human Islets” (NIH
R21DK068854), Principal Investigator - Alvin C. Powers, 08/01/04-12/31/06.
22. National Institutes of Health, “Pancreatic Islet Imaging and Blood Flow” (NIH
R01DK068764), Principal Investigator - Alvin C. Powers, 08/01/04-07/31/08.
23. Juvenile Diabetes Research Foundation, “Identification of Genes Activated in Human Islet
Hyperplasia”, Principal Investigator - Alvin C. Powers, 09/01/08 – 08/31/09.
24. Juvenile Diabetes Research Foundation, “Islet Transcription Factors in Human Islets“,
Principal Investigator - Alvin C. Powers, 02/01/07 – 01/31/10.
25. National Institutes of Health, “VEGF and Islet Vascularization” (NIH R01 DK069603),
Principal Investigator - Alvin C. Powers, 07/01/05-06/30/20010.
26. Juvenile Diabetes Research Foundation, “Human Beta Cell Proliferation in Humanized
Mice”, (PI – Greiner; Co-investigators - Shultz, Powers), 09/01/08-08/31/10.
27. National Institutes of Health, Beta Cell Biology Consortium (DK072473, Magnuson, PI),
Collaborative Bridging Project, “Humanized Mice for Assays to Normalize Endocrine
Pancreas Function” (PI – Herrera; Co-investigators - Greiner, Shultz, Powers), 10/01/08-
08/31/10
28. Veterans Administration Merit Review Award - ”Islet Vascularization and Islet Function in
Type 2 diabetes”, Principal Investigator - Alvin C. Powers, 10/01/04-09/30/10.
29. National Institutes of Health, Beta Cell Biology Consortium (DK072473, Magnuson, PI),
“Approaches to Study Human Islet Proliferation”, (Powers – PI of this project), 03/1/09-
12/31/10
30. National Institutes of Health, Beta Cell Biology Consortium (DK072473, Magnuson, PI),
“Multi-modal Imaging of Beta Cells”, (Schneider – PI of this project, Powers, co-
investigator), 03/01/09-12/31/10
31. National Institutes of Health, Beta Cell Biology Consortium (DK072473, Magnuson, PI),
“Friendly Immunosuppression for Endocrine Regeneration”, (Powers – PI of this project),
01/01/09-12/31/10
32. National Institutes of Health, “GLP-1 to Enhance Islet Transplantation” (NIH R21/R33-
DK66636), Principal Investigator - Alvin C. Powers, 09/30/03-06/30/11.
33. Juvenile Diabetes Research Foundation, “Endothelial Cells and Islet Regeneration”,
Principal Investigator - Alvin C. Powers, 07/01/08 – 06/30/11.
34. Juvenile Diabetes Research Foundation, “New Imaging Agents Targeting VMAT-2”,
Principal Investigator - Alvin C. Powers, 09/01/08 – 08/31/11
35. Juvenile Diabetes Research Foundation, “ErbB Receptors and Islet Regeneration”,
Principal Investigator - Alvin C. Powers, 09/01/08 – 08/31/11
36. Juvenile Diabetes Research Foundation, “Stimulation of Alpha Cell Hyperplasia”, Principal
Investigator - Alvin C. Powers, 08/01/10 – 07/31/11.
37. National Institutes of Health, Beta Cell Biology Consortium (DK072473, Magnuson, PI),
“From Fish to Man” (FFTM)”, (Powers – co-investigator of this project), 03/01/11-2/29/13
38. National Institutes of Health, “Molecular mechanisms underlying NHP pancreatic beta cell
failure and recovery”, (R24 DK093437, David Harlan, contact PI), Principal Investigator
(multi PI/PD project) – Alvin C. Powers, 09/01/11 – 08/30/13
39. National Institutes of Health, “Reconstruction of Human Type 1 Diabetes in Mice”, (R24
DK092758, Doug Melton, contact PI), Principal Investigator (multi PI/PD project) – Alvin C.
Powers, 09/30/11 – 08/30/13
40. Juvenile Diabetes Research Foundation, “Novel Pathways and Targets for Promoting Beta
Cell Regeneration,” Principal Investigator – Philipp Scherer; Co-investigator - Alvin C.
Powers, 04/01/12 – 03/31/14.
Alvin Carter Powers, MD, Curriculum Vitae - Page 15
41. Juvenile Diabetes Research Foundation, “ID of factors stimulating alpha cell proliferation,”
Principal Investigator - Alvin C. Powers, 04/01/13 – 03/31/15.
42. National Institutes of Health (NIDDK – Beta Cell Biology Consortium), “Multi-Disciplinary
Approaches to Driving Therapeutic Human Beta Cell Replication” (NIH U01DK089538),
Principal Investigators – Andrew Stewart, Alvin C. Powers (Stewart as contact PI),
08/01/10-06/30/15.
43. National Institutes of Health, Beta Cell Biology Consortium (DK072473, Magnuson, PI),
“HIDEF: Human Islet Development and Function”, (Powers – PI of this project), 03/01/11-
7/31/15
44. National Institutes of Health (NIDDK – Beta Cell Biology Consortium), “Molecular
Mechanisms of Human and Murine Beta Cell Proliferation and Regeneration” (NIH
U01DK089572), Principal Investigator - Alvin C. Powers, 08/01/10-06/30/16.
45. Juvenile Diabetes Research Foundation, “Targeting Pancreatic Islet Endocrine Cells with
Nucleic Acid Aptamers,” Principal Investigator - Alvin C. Powers, 06/01/13 – 05/31/17.
46. National Institutes of Health, “Islet Imaging with Monoclonal Antibodies,” (R01DK094199),
Principal Investigator - Alvin C. Powers, 12/01/11 – 8/30/17.
47. Juvenile Diabetes Research Foundation, “Nano-sponges for human islet cell targeting,”
Principal Investigator - Alvin C. Powers, 06/01/13 – 05/31/17.
48. Juvenile Diabetes Research Foundation, “Alpha cell plasticity in human T1D,” Co-
investigator; Marcela Brissova, Principal Investigator) -, 06/01/15 – 05/31/17
49. National Institutes of Health, “Islet Biology in Cystic Fibrosis Related Diabetes”,
(R01DK097829), Principal Investigator - Alvin C. Powers (Co-PI with Lydia Aguilar-Bryan),
09/15/12 – 03/31/18.
Publications and Presentations
:
Articles in refereed journals (published or under review):
1. Abrahamson DR, Powers AC
, Rodewald R: Intestinal absorption of immune complexes by
neonatal rats: A route of antigen transfer from mother to young. Science 296:567-568,
1979
2. Duckworth WC, Solomon SS, Jallepalli P, Heckemeyer C, Finnern J, Powers AC: Glucose
intolerance due to insulin resistance in patients with spinal cord injuries. Diabetes 29:206-
210, 1980
3. Powers AC, Solomon SS, Duckworth WC: Insulin degradation by mononuclear cells.
Diabetes 29:27-31, 1980
4. Powers AC, Rabizadeh A, Akeson R, Eisenbarth GS: Characterization of monoclonal
antibody 3G5 and utilization of this antibody to immobilize pancreatic islet cell gangliosides
in solid-phase radioassay. Endocrinology 114:1338-1343, 1984
5. Powers AC, Eisenbarth GS: Autoimmunity to islet cells in diabetes mellitus. Ann Rev Med
36:533-544, 1985
6. James DE, Zorzano A, Boni-Schnetzler M, Nemenoff RA, Powers AC, Pilch PF,
Ruderman NB: Intrinsic differences of insulin receptor kinase activity in red and white
muscle. J Biol Chem 261:14939-14944, 1986
7. Kwok YC, Nemenoff RA, Powers AC, Avruch J: Kinetic properties of the insulin receptor
tyrosine protein kinase: activation through an insulin-stimulated tyrosine-specific
intramolecular autophosphorylation. Archives of Biochemistry & Biophysics 244:102-113,
1986
8. Philippe J, Powers AC, Brand SI: Cholecystokinin and glucagonoma (letter). N Engl J Med
318:121-122, 1988
Alvin Carter Powers, MD, Curriculum Vitae - Page 16
9. Philippe J, Powers AC, Mojsov S, Cosmi R, Habener JF: Expression of polypeptide
hormone genes in human islet cell tumors. Diabetes 37:1647-1651, 1988
10. Powers AC, Philippe J, Hermann H, Habener JF: Sodium butyrate increases glucagon and
insulin gene expression by recruiting immunocytochemically negative cells to produce
hormone. Diabetes 37:1405-1410, 1988
11. Jameson JL, Powers AC, Gallagher GD, Habener JF: Enhancer and promoter element
interactions dictate cyclic adenosine monophosphate mediated and cell-specific
expression of the glycoprotein hormone alpha gene. Mol Endocrinol 3:763-772, 1989
12. Powers AC, Tedeschi F, Wright KE, Chan JS, Habener JF: Somatostatin gene expression
in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding
proteins. J Biol Chem 264:10048-10056, 1989
13. Ron D, Powers AC, Pandian MR, Godine J, Axelrod L: Increased insulin-like growth factor
II (IGF-II) production and consequent suppression of growth hormone secretion: a dual
mechanism for tumor induced hypoglycemia. J Clin Endocrinol Metab 68:701-706, 1989
14. Powers AC, Efrat S, Mojsov S, Spector D, Habener JF, Hanahan D: Proglucagon
processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic
mouse tumor. Diabetes 39:406-414, 1990
15. Whitesell RR, Powers AC, Regen DM, Abumrad NA: Transport and metabolism of glucose
in an insulin-secreting cell line, beta TC-1. Biochemistry 30:11560-11566, 1991
16. Pietropaolo M, Castaño L, Babu S, Buelow R, Kuo Y-LS, Martin S, Martin A, Powers AC,
Prochazka M, Naggert J, Leiter EH, Eisenbarth GS: Islet Cell Autoantigen 65 kD (ICA69):
molecular cloning and characterization of a novel diabetes-associated autoantigen. J Clin
Invest 92:359-371, 1993
17. Whitesell RR, Aboumrad MK, Powers AC, Regen DM, Le C, Beechem JM, May JM,
Abumrad NA: Coupling of glucose transport and phosphorylation in Xenopus oocytes and
cultured cells: determination of the rate-limiting step. Journal of Cellular Physiology
157:509-513, 1993
18. Morita H, Yano Y, Niswender KD, May JM, Whitesell RR, Wu L, Printz RL, Granner DK,
Magnuson MA, Powers AC
: Coexpression of glucose transporters and glucokinase in
Xenopus oocytes indicates that both glucose transport and phosphorylation determine
glucose utilization. J Clin Invest 94:1373-1382, 1994
19. Ujihara N, Daw K, Gianani R, Boel E, Yu L, Powers AC: Identification of glutamic acid
decarboxylase autoantibody heterogeneity and epitope regions in Type I diabetes.
Diabetes 43:968-975, 1994
20. Schmidli RS, Colman PG, Bonifacio E, Bottazzo GF, Harrison LC, Participating
Laboratories: High level of concordance between assays for glutamic acid decarboxylase
antibodies: the first international glutamic acid decarboxylase antibody workshop. Diabetes
43:1005-1009, 1994
21. Daw K, Powers AC
: Two distinct glutamic acid decarboxylase autoantibody specificities in
IDDM target different epitopes. Diabetes 44:216-220, 1995
22. Due AD, Cook JA, Fletcher SJ, Zhi-chao Q, Powers AC, May JM: A "cysteineless" GLUT1
glucose transporter has normal function when expressed in Xenopus oocytes. Biochem
Biophys Res Comm 208:590-596, 1995
23. Due AD, Zhi-chao Q, Thomas JM, Buchs A, Powers AC, May JM: The role of the C-
terminal tail of the GLUT1 glucose transporter in its expression and Function in Xenopus
laevis oocytes. Biochemistry 34:5462-5471, 1995
24. Schmidli RS, Colman PG, Bonifacio E, and participating laboratories: Disease sensitivity
and specificity of fifty-two assays for glutamic acid decarboxylase antibodies: the second
international glutamic acid decarboxylase antibody workshop. Diabetes 44:636-640,1995
Alvin Carter Powers, MD, Curriculum Vitae - Page 17
25. Vinik AI, Leichter SB, Pittenger GL, Stansberry KB, Holland MT, Powers AC,
Suwanwalaikorn S: phospholipid and glutamic acid decarboxylase autoantibodies in
diabetic neuropathy. Diabetes Care 18:1225-1232,1995
26. Buchs A, Wu L, Morita H, Whitesell RR, Powers AC: Two regions of GLUT 2 glucose
transporter protein are responsible for its distinctive affinity for glucose. Endocrinology
136:4224-4230, 1995
27. Daw K, Ujihara N, Atkinson M, Powers AC: Glutamic acid decarboxylase autoantibodies in
Stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and
differences in epitope recognition. Journal of Immunology,156:818-825, 1996
28. Bhisitkul DM, Vinik AI, Morrow AL, She JX, Shults J, Powers AC, Maclaren NK:
Prediabetic markers in children with stress hyperglycemia. Archives of Pediatrics &
Adolescent Medicine 150:936-941, 1996
29. Weaver CD, Yao TL, Powers AC, Verdoorn TA: Differential expression of glutamate
receptor subtypes in rat pancreatic islets. Journal of Biologic Chemistry 271: 12977-
12984, 1996
30. Wandel S, Buchs A, Schurmann A, Summers SA, Powers AC, Shanahan MF, Joost HG:
Glucose transport activity and ligand binding (cytochalasin B, IAPS-forskolin) of chimeric
constructs of GLUT2 and GLUT4 expressed in COS-7 cells. Biochim Biophys Acta
1284:56-62, 1996
31. Brissova M, Lacik I, Powers AC, Wang TG: Evaluation of microcapsule permeability via
inverse size exclusion chromatography. Anal Biochem 242:104-111, 1996
32. Ziegler B, Schlosser M, Lühder F, Strebelow M, Augstein P, Northemann W, Powers AC,
Ziegler M: Murine monoclonal GAD65-antibodies recognize autoimmune associated GAD
epitope regions targeted in IDDM and Stiff-man syndrome. Acta Diabetologica 33:225-
231, 1996
33. Wang TG, Prokop A, Green R, Brissova M, Lacik I, Anilkumar AV, Shahrokhi K, Powers
AC: An encapsulation system for the immunoisolation of pancreatic islets. Nature
Biotechnology15:358-362, 1997
34. Lacik I, Brissova M, Anilkumar AV, Powers AC, Wang TG: New capsule with tailored
properties for the encapsulation of living cells. Journal of Biomedical Materials Research
39:52-60, 1998
35. Brissova M, Lacik I, Powers AC, Anilkumar AV, Wang TG: Control and measurement of
permeability for design of microcapsules for cell delivery system. Journal of Biomedical
Materials Research 39:61-70, 1998
36. Fritz JD, Utz AL, Hale NM, Northington SJ, Wu L, Powers AC, Verdoorn TA, Robertson D:
Gene-based modulation of neurotransmitters in cerebellar granule neurons. Journal of
Neurochemistry 68:204-212, 1997
37. Hunkeler D, Prokop A, Powers AC, Haralson M, DiMari S, Wang TG: A screening of
polymers as biomaterials for cell encapsulation. Polymer News 22:232-240, 1997
38. Tremble J, Morgenthaler NG, Vlug A, Powers AC, Christie MR, Scherbaum WA, Banga
JP: Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a
non-diabetic patient with multiple autoantibodies and Graves disease: a comparison with
those present in Type I diabetes. J Clin Endocrinol Metab 82:2664-2670, 1997
39. Powers AC, Brissova M, Lacik I, Anilkumar AV, Shahroki K, Wang TG: Permeability
assessment of capsules for islet transplantation. Annals of the New York Academy of
Sciences 831:208-216, 1997
40. Prokop A, Hunkeler D, Powers AC, Whitesell RR, Wang TG: Water soluble polymers for
immunoisolation II: evaluation of multicomponent microencapsulation systems. Advances
in Polymer Science 136:53-73, 1998
41. Wu L, Fritz JD, Powers AC: Different functional domains of GLUT2 glucose transporter are
required for glucose affinity and substrate specificity. Endocrinology 139:4205-4212, 1998.
Alvin Carter Powers, MD, Curriculum Vitae - Page 18
42. Verge CF, Stenger D, Bonifacio E, Colman PG, Pilcher C, Binglet PJ, George Eisenbarth
and Participating Laboratories: Combined use of autoantibodies (IA-2 autoantibody, GAD
autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in Type I diabetes:
Combinatorial islet autoantibody workshop. Diabetes 47:1857-1866, 1998
43. Powers AC
, Bavik K, Tremble J, Banga JP. Comparative analysis of epitope recognition
of glutamic acid decarboxylase (GAD) by autoantibodies from different autoimmune
disorders. Clin Exp Immunol 118:349-356, 1999.
44. Muller M, Brissova M, Rieser T, Powers AC, Lunkwitz K: Deposition and properties of
polyelectrolyte multilayers studied by ATR-FITR Spectroscopy. Materials Science &
Engineering C, vol. 8-9, p. 167-173 (1999)
45. Perriott LM, Kono T, Whitesell RR, Knobel S, Piston D, Granner DK, Powers AC, May JM:
Glucose uptake and metabolism by cultured human skeletal muscle cells: rate-limiting
steps. AJP, Endocrinology and Metabolism 281:E72-80, 2001
46. Brissova M, Shiota M, Gannon M, Nicholson W, Knobel S, Piston DW, Wright CVE,
Powers AC
: Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated
insulin secretion. Journal of Biological Chemistry 277:11225, 2002
47. Boord J, Graber AL, Christman JW, Powers AC: Practical Management of Diabetes in
Critically Ill Patients. American Journal of Respiratory and Critical Care Medicine
164:1763-7, 2001
48. Rocheleau JV, Head WS, Nicholson WE, Powers AC, Piston DW: Pancreatic islet beta -
cells transiently metabolize pyruvate. Journal of Biological Chemistry 277:30914-30920,
2002
49. Brissova M, Nicholson WE, Shiota M, Powers AC: Assessment of insulin secretion in the
mouse. Methods in Molecular Medicine 83:23, 2003.
50. Wu L, Nicholson WE, Wu CY, Xu M, Gregory S, McGaha A, Shiota M, Powers AC:
Engineering physiologically regulated Insulin in non-Beta islet cells by expressing
glucagon-like peptide 1 receptor. Gene Therapy 10:1712-20, 2003.
51. Gustavson SM, Nishizawa M, Farmer B, Neal D, Brissova M, Powers AC, Cherrington AD:
Fall in portal vein insulin does not cause the alpha cell response to mil, non-insulin-
induced hypoglycemia in conscious dogs. Metabolism 52:1418-1425, 2003.
52. Solomon SS, Tom SC, Pichert J, Wasserman D, Powers AC: Impact of medical student
research in the development of physician-scientists, Journal of Investigative Medicine
51:149-56, 2003
53. Brissova M, Fowler M, Wiebe P, Shostak A, Shiota M, Radhika A, Lin PC, Gannon M, and
Powers AC
: Intra-islet Endothelial Cells Contribute to Revascularization of Transplanted
Pancreatic Islets. Diabetes 53:1318-1325, 2004
54. Wu L, Nicholson W, Knobel SK, Steffner RJ, May JM, Piston DW, Powers AC: Oxidative
Stress Mediates the Toxic Oxidative Stress is a Mediator of Glucose Toxicity in Insulin-
secreting Pancreatic β Cells. Journal of Biological Chemistry 279:12126-34, 2004
55. Hu X, Friedman D, Hill S, Caprioli R, Powers AC, Hunter L, Limbird LE: Proteomic
exploration of pancreatic islets from mice lacking expression of the insulin release-
suppressing α2A adrenergic receptor. Journal of Molecular Endocrinology 35:73-88, 2005.
56. Steffner RT, Wu L, Powers AC, May JM. Ascorbic acid recycling by cultured beta cells:
effects of glucose toxicity. Free Radical Biology and Medicine 37:1612-21, 2004.
57. Brissova M, Fowler M, Chu A, Hirschberg B, Harlan D, Powers AC. Assessment of human
pancreatic islet architecture and composition by laser scanning confocal microscopy.
Journal of Histochemistry & Cytochemistry 53(9):1087-97, 2005
58. Whitesell RR, Ardehali H, Beechem JM,
Powers AC, Van Der Meer W, Perriott LM, Daryl
K. Granner DK: Compartmentalization of Transport and Phosphorylation of Glucose in a
Hepatoma Cell Line. Biochemical Journal 86:245-53, 2005
Alvin Carter Powers, MD, Curriculum Vitae - Page 19
59. Fowler MJ, Virostko J, Chen Z, Poffenberger G, Radhika A, Brissova M, Shiota M,
Nicholson WE, Shi Y, Hirshberg B, Harlan DM, Jansen ED, Powers AC
: Assessment of
Pancreatic Islet Mass after Islet transplantation using In Vivo Bioluminescence Imaging.
Transplantation 79:768-776, 2005
60. Powers AC and Jansen ED: In vivo bioluminescence imaging to assess pancreatic islets.
Current Medicinal Chemistry 4:339-348, 2004
61. Virostko J, Fowler M, Chen Z, Powers AC, Jansen ED: Factors influencing quantification
of in vivo bioluminescence imaging: application to assessment of pancreatic islet
transplants. Molecular Imaging 4:1-10, 2004
62. Brissova
,
M, Blaha
M, Spear
C, Nicholson
W, Radhika
A, Shiota
M, Charron
MJ, Wright
CVE, Powers
AC: Reduced PDX-1 Expression impairs islet response to insulin resistance
and worsens glucose homeostasis: American Journal of Physiology - Endocrinology and
Metabolism 288:E707-14, 2005
63. Nguyen, CV, Powers AC, Greenspan DL, Elasy TA. Diabetes referrals at a Veterans
Administration Tertiary Facility: Who are the patients and why are they referred? Diabetes
Care 28:423-424, 2005
64. Smith SJ, Zhang H, Clermont AO, Powers AC, Kaufman DB, Purchio AF, West DB: In vivo
monitoring of pancreatic beta-cell mass and function in a transgenic mouse model.
Molecular Imaging 5:65-75, 2006
65. Park S., Wang X., Chen Z., Powers AC, Magnuson MA, Head WS. Piston DW, Bell GI:
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I
promoter-firefly luciferase transgene. Genesis 43:80-86, 2005
66. Wetzel JD, Barton ES, Campbell JD, Baer GS, Mochow-Grundy M, Rodger SE, Shyr Y.
Powers AC
, Thomas JW, Dermody TS: Reovirus delays diabetes onset but does not
prevent insulitis in non-obese diabetic mice, Journal of Virology 80:3078-82, 2006
67. Nunemaker CS, Zhang M, Wasserman DH, McGuinness OP, Powers AC, Bertram R,
Sherman A, Satin LS. Individual mice can be distinguished by the period of their islet
calcium oscillations: is there an intrinsic islet period which is imprinted in vivo. Diabetes
54:3517-22, 2005
68. Atouf F, Choi Y, Fowler MJ, Poffenberger G, Vobecky J, Ta M, Chapman GB, Powers AC,
Lumelsky N. Generation of islet-like hormone producing cells in vitro from adult human
pancreas, Cell Transplantation 14:735-48, 2005
69. Blomeier H, Zhang Z, Rives C, Brissova M, Hughes E, Baker M, Powers AC, Kaufman DB,
Shea LD, Lowe WL. Polymer scaffolds as synthetic microenvironments for extrahepatic
islet transplantation. Transplantation 82(4):452-459, 2006
70. Brissova
M, Shostak
,
A, Shiota
M, Wiebe
PO, Poffenberger
G, Kantz
J, Chen
Z, Carr
C,
Jerome
WG, Chen
J, Baldwin
HS, Nicholson
W, Bader
DM, Jetton
T, Gannon
M, and
Powers AC
. Pancreatic Islet Production of VEGF-A is Essential for Islet Vascularization,
Revascularization and Function. Diabetes 55:2974-2985, 2006
71. Roth DJ, Jansen ED, Powers AC, Wang TG. A novel method of monitoring response to
islet transplantation: bioluminescent imaging of an NF-kB transgenic mouse model.
Transplantation 81:1185-90, 2006
72. Virostko J, Jansen ED, Powers AC. Current status of islet imaging. Curr Diab Rep. 6:328-
32, 2006
73. Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV. Complementation
rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-
regulatory sequences in pancreatic and duodenal expression. Dev Biol 298:616, 2006
74. Tweedie E, Wilding L, Poffenberger G, Powers AC, Gannon M. Maintenance of Hnf6 in
postnatal islets impairs terminal differentiation and function of beta cells, Diabetes
55:3264-70, 2006
Alvin Carter Powers, MD, Curriculum Vitae - Page 20
75. Virostko J, Powers AC, Jansen ED. Validation of luminescent source reconstruction using
single-view spectrally resolved bioluminescence images. Appl Opt 46:2540, 2007
76. Berglund ED, Li CY, Poffenberger G, Ayala JE, Fueger PT, Willis SE, Jewell MM, Powers
AC, Wasserman DH. Glucose metabolism in vivo in four commonly used inbred mouse
strains. Diabetes 57:1790, 2008 PMCID: PMC2453626
77. Nyman
LR, Wells
KS, Head WS, McCaughey M, Ford E, Brissova
M, Piston DW, Powers
AC. Real-Time, Multidimensional, In Vivo Imaging Used to Investigate the Relationship
Between Pancreatic Islet Architecture and Blood Flow. Journal of Clinical Investigation
118:3790, 2008 PMCID: PMC2564611
78. Virostko J, Radhika A, Poffenberger G, Chen Z, Brissova M, Gilchrist J, Coleman B,
Gannon M, Jansen ED, Powers AC. Bioluminescence Imaging in Mouse Models Reflects
β Cell Mass in the Pancreas and After Islet Transplantation. Molecular Imaging and
Biology 12:42, 2010 PMCID: PMC3822006
79. Cheng Q, Kantz J, Poffenberger G, Powers AC, Gailani D. Factor XI protein in human
pancreas and kidney. Thrombosis and Haemostasis 100:158, 2008 PMCID: PMC2690650
80. Brissova M, Powers AC. Revascularization of Transplanted Islets: Can It Be Improved?
Diabetes 57: 2269, 2008 PMCID: PMC2518476
81. Powers AC. Insulin Therapy versus Cell-Based Therapy for Type 1 Diabetes – What is
ahead? Nature Clinical Practice Endocrinology & Metabolism 4:664, 2008 PMCID:
PMC3740175
82. Virostko J and Powers AC. Molecular Imaging of the Pancreas in Small Animal Models,
Gastroenterology 136:407, 2009 PMCID: PMC3740180
83. Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F,
MacDonald RJ, Ferrer J, Wollheim CB. PDX1 deficiency causes mitochondrial dysfunction
and defective insulin secretion through TFAM suppression. Cell Metabolism 10:110, 2009
PMCID: PMC4012862
84. Nyman LR, Ford E, Powers AC*, Piston DW* (*corresponding authors). Glucose-
dependent blood flow dynamics in murine pancreatic islets in vivo. Am J Physiol
Endocrinol Metab 298:E807-14, 2010 PMCID:PMC2853211
85. Zhao A, Ohara-Imaizumi M, Brissova M, RKP Benniger, Xu Y, Hao Y, Abramowitz J,
Boulay G, Powers AC, Piston D, Jiang M, Nagamatsu S, Birnbaumer L, Gu G.
Gαo
represses insulin secretion by reducing vesicular docking in pancreatic β cells. Diabetes
59:2522, 2010 PMCID: PMC3279551
86. Wicksteed B*, Brissova M, Yan
W, Opland
DM, Plank
JL, Reinert
RB, Dickson
LM,
Tamarina
NA, Philipson
LH, Shostak
A, Bernal-Mizrachi
E, Elghazi
L, Roe
MW, Labosky
PA, Myers MM, Gannon
M, Powers AC*, Dempsey PJ* (*corresponding authors).
Conditional gene targeting in mouse pancreatic β-cells: Analysis of ectopic Cre transgene
expression in the brain, Diabetes 59:3090, 2010 PMCID: PMC2992770
87. Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski
L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD. Human Immune System
Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-
Rag1null IL2r{gamma}null Ins2Akita Mice. Diabetes
59:2265, 2010 PMCID: PMC2927949
88. Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH,
Powers AC, Brown NJ. Aldosterone decreases glucose-stimulated insulin secretion in vivo
in mice and in murine islets. Diabetologia 54:2152, 2011 PMCID: PMC3216479
89. Dilorio P, Jurczyk A, Yang C, Racki W, Brehm MA, Atkinson MA, Powers AC, Shultz LD,
PhD, Greiner DL, Bortell R, Hyperglycemia-induced Proliferation of Adult Human Beta
Cells Engrafted into Spontaneously Diabetic Immunodeficient NOD-Rag1null IL2rg null
Ins2Akita Mice. Pancreas 40:1147, 2011 PMCID: PMC3176417
90. Virostko
J, Henske
J, Radhika
A, Vinet
L, Lamprianou
S, Baldwin
RM, Ansari
MS, Hefti
F,
Skovronsky
D, Kung
HF, Herrera
PL, Peterson
TE, Meda
P, Powers
AC. Multimodal Image
Alvin Carter Powers, MD, Curriculum Vitae - Page 21
Co-registration and Inducible Selective Cell Ablation to Evaluate Imaging Ligands
Inducible Selective Cell Ablation and Multimodal Image Co-registration to Evaluate
Imaging Ligands, Proceedings of the National Academy of Science 108:20719, 2011
PMCID: PMC3251115
91. Dai C, Brissova M, Hang Y, Poffenberger G, Shostak A, Chen Z, Stein R, Powers AC.
Islet-Enriched Gene Expression and Glucose-Induced Insulin Secretion in Human Islets,
Diabetologia 55:707, 2012 PMCID: PMC3391601
92. Reinert
RB, Kantz
J, Ackermann-Misfeldt
A, Poffenberger
G, Gannon M, Brissova
M,
Powers AC. Tamoxifen-Induced Cre-loxP Recombination is Prolonged in Pancreatic Islets
of Adult Mice, PLoS One 7:e33529, 2012 PMCID: PMC3314663
93. Cai
Q, Brissova M, Reinert RB, Pan FC, Brahmachary P, Jeansson M, Shostak A, Radhika
A, Poffenberger G, Quaggin SE, Jerome WG, Dumont DJ, Powers AC. Enhanced
expression of VEGF-A in β cells increases endothelial cell number but impairs islet
morphogenesis and β cell proliferation, Developmental Biology 367:40, 2012 PMCID:
PMC3391601
94. Christoffersson G, Vågesjö E, Vandooren J, Lidén M, Massena S, Reinert RB, Brissova M,
Powers AC, Opdenakker G, Phillipson M. VEGF-A recruits a proangiogenic MMP-9-
delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue.
Blood 120:4653, 2012 PMCID: PMC3512240
95. Longuet C, Robledo AM, Dean ED, Dai C, Ali S, McGuinness I, de Chavez V, Vuguin PM,
Charron MJ, Powers AC*, Drucker DJ*. (*corresponding authors). Liver-Specific Disruption
of the Murine Glucagon Receptor Produces α-Cell Hyperplasia: Evidence for a Circulating
α-Cell Growth Factor, Diabetes 62:1196, 2013 PMCID: PMC3609565
96. Kaddis JS, Hanson MS, Cravens J, Qian D, Olack
B, Antler
M, Papas KK, Iglesias I,
Barbaro B, Fernandez L, Powers AC, Niland JC. Standardized Transportation of Human
Islets: An Islet Cell Resource Center Study of Over 2,000 Shipments, Cell Transplantation
22:1101, 2013 PMCID: PMC3745279
97. Dai C, Brissova M, Reinert
RB, Poffenberger G, Thompson C, Shostak A, Shiota M,
Takahashi T, Powers AC. Pancreatic Islet Vasculature Adapts to Insulin Resistance
through Dilation and Not Angiogenesis, Diabetes 62:4144, 2013 PMCID: PMC3837044
98. Virostko
J, Radhika
A, Poffenberger G, Dula AN, Moore DJ, Powers
AC. Bioluminescence
Imaging Reveals Dynamics of Beta Cell Loss in the Non-obese Diabetic (NOD) Mouse
Model, PLoS ONE 8:e57784, 2013 PMCID: PMC3590285
99. Guo S, Dai C, Guo M, Taylor B, Harmon JS, Sander M, Robertson RP, Powers AC, Stein
R. MafA, MafB, Nkx6.1 and Pdx1 inactivation in Type 2 diabetes, Journal of Clinical
Investigation 123:3305, 2013 PMCID: PMC3726150
100. Reinert
RB, Brissova
M, Pan FC, Poffenberger G, Cai
Q, Hundemer GL, Kantz J,
Thompson CD, Dai C, Powers AC. Vascular Endothelial Growth Factor-A and Islet
Vascularization are Necessary in Developing, but not Adult, Pancreatic Islets, Diabetes
62:4154, 2013 PMCID: PMC3837071
101. Campbell-Thompson, ML, Atkinson, MA, Butler, AE, Chapman, NM, Frisk, G, Gianani, R,
Giepmans, B.N, Herrath, M.G, Hyöty, H, Kay, T.W, Korsgren, O Morgan, NG, Powers, AC,
Pugliese, A, Richardson, SJ, Rowe, PA, Tracy, S, In’t Veld, PA. The diagnosis of insulitis
in human type 1 diabetes. Diabetologia 56:2541, 2013 PMID: 24006089 (Letter to Editor)
102. Reinert RB, Cai Q, Hong JY, Plank JL, Aamodt K, Prasad N, Aramandla R, Dai C, Levy
SE, Pozzi A, Labosky PA, Wright CV, Brissova M, Powers AC. Vascular Endothelial
Growth Factor Coordinates Pancreatic Islet Vascularization, Innervation, and
Neurovascular Alignment Via Islet-Endothelial Cell-Neuronal Signaling Network,
Development 141:1480, 2014 PMCID: PMC3957372
103. Brissova M, Aamodt K, Brahmachary P, Prasad N, Hong JY, Dai C, Mellati M, Shostak A,
Poffenberger G, Aramandla R, Levy SE, Powers AC. Islet microenvironment, modulated
Alvin Carter Powers, MD, Curriculum Vitae - Page 22
by vascular endothelial growth factor-A signaling, promotes β cell regeneration, Cell
Metabolism 19:498, 2014 PMCID: PMC4012856
104. Hang Y, Yamamoto T, Benninger RK, Brissova M, Guo M, Thompson FH, Bush W, Piston
D, Powers AC, Magnuson M, Thurmond D, Stein R. The MafA transcription factor
becomes essential to islet β-cells soon after birth. Diabetes 63:1994, 2014 PMCID:
PMC4030115
105. Kang L, Dai
C, Lustig
ME, Bonner
JS, Mayes
WH, Mokshagundam
S, James
FD,
Thompson
CS, Lin
C, Perry
CGR, Anderson
EJ, Neufer
PD, Wasserman
DH, Powers AC.
SOD2: Pivotal Regulator of Insulin Secretion but not Insulin Action in High Fat-Fed Mice.
Diabetes 63:3699, 2014 PMCID: PMC4207395
106. Dai C, Liu E, Fiaschi-Taesch N, Keller MP, Shostak A, Cai Q, Thompson C, Pan FC, Attie
AD, Harlan DM, Powers AC. Central role of CDK1 in beta-cell proliferation in a super-
obese human. Submitted
107. Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC,
Rhodes CJ, Sussel L, Weir GC. β-cell Failure in Type 2 Diabetes: Postulated Mechanisms
and Prospects for Prevention and Treatment. J Clin Endocrinol Metab 99:1983, 2014; also
published in Diabetes Care 7:1751, 2014 PMCID: PMC4179518
108. Dou S, Virostko J, Rusckowski M, Greiner DL, Powers AC, Liu G. Differentiation between
temporary and real non-clearability of biotinylated IgG antibody by avidin in mice. Frontiers
in Pharmacology, Section of Experimental Pharmacology and Drug Discovery 5:172, 2014
PMCID: PMC4109569
109. Patel M, Gleason A, O'Malley S, Connolly B, Suresch D, Virostko J, Phillips N, Lin S, Chen
T, Klimas M, Hargreaves RJ, Sur C, Williams DL, Powers AC, Bednar B. Non-Invasive
Bioluminescence Imaging of β-Cell Function in Obese-Hyperglycemic [ob/ob] Mice. PLoS
One 9(9):e106693, 2014 PMCID: PMC4157804
110. Dou S, Virostko J, Greiner DL, Powers AC, Liu G. A feasible approach to evaluate the
relative reactivity of NHS-ester activated group with primary amine-derivatized DNA
analogue and non-derivatized impurity. Nucleosides, Nucleotides and Nucleic Acids
Nucleosides Nucleotides Nucleic Acids 34:69, 2015 PMCID: PMC4398971
111. Shah SS, Ramirez CE, Powers AC, Yu C, Shibao CA, Luther JM. Hyperglycemic clamp-
derived disposition index is negatively associated with metabolic syndrome severity in
humans. Metabolism 65:835, 2016 PMCID: PMC4867079
112. Burke SJ, May AL, Noland RC, Lu D, Brissova M, Powers AC, Sherrill EM, Karlstad MD,
Campagna SR, Stephens JM, Collier JJ. Thiobenzothiazole-modified Hydrocortisones
Display Anti-inflammatory Activity with Preservation of Islet β-cell Function. Journal of
Biological Chemistry 290:13401, 2015 PMCID: PMC4505588
113. Brissova M, Shostak A, Fligner CL, Revetta F, Washington MK, Powers AC, Hull RL.
Human Islets Have Fewer Blood Vessels Than Mouse and The Density of Islet Vascular
Structures Increases in Type 2 Diabetes.
Journal of Histochemistry & Cytochemistry
63:637, 2015 PMCID: PMC4530394
114.
Kayton NS, Poffenberger G, Henske J, Dai C, Thompson C, Aramandla R, Shostak A,
Nicholson W, Brissova M, Bush WS, Powers AC. Human Islet Preparations Distributed for
Research Exhibit a Variety of Insulin Secretory Profiles. American Journal of Physiology -
Endocrinology and Metabolism 308:E592, 2015
PMCID: PMC4385877
115.
Conrad E, Dai C, Spaeth J, Guo M, Goodrich L, Harlan DM, Grove KL, Powers AC, Gu G,
Stein R. The MAFB transcription factor impacts islet α-cell function in rodents and
represents a unique signature of primate islet β-cells. American Journal of Physiology -
Endocrinology and Metabolism 310:E91, 2016 PMCID: PMC4675799
116. Dou S, John Virostko J, Greiner DL, Powers AC, Guozheng Liu G. Quantitative correlation
of in vivo properties with in vitro assay results — the in vitro binding of a biotin-DNA analog
Alvin Carter Powers, MD, Curriculum Vitae - Page 23
modifier with streptavidin predicts the in vivo avidin-induced clearability of the analog-
modified antibody. Molecular Pharmaceutics 12:3097, 2015 PMCID: PMC4711347
117.
Ceddia RP, Lee DK, Maulis MF, Carboneau BC, Threadgill DW, Poffenberger G, Milne G,
Powers AC, McGuinness OP, Gannon M, Breyer RM. The PGE2 EP3 receptor regulates
diet-1 induced adiposity in male mice. Endocrinology 157:220, 2016 PMCID:
PMC4701878
118.
Alfa RW, Park S, Skelly KR, Poffenberger G, Jain N, Gu X, Kockel L, Jing Wang J,
Yinghua Liu Y, Powers AC, Kim SK. Suppression of insulin production and secretion by a
decretin hormone. Cell Metabolism 21:323, 2015 Cell Metabolism 21:323, 2015 PMCID:
PMC4349554
119. Zhu X, Hu R, Brissova M, Stein RW, Powers AC, Gu G, Kaverina I. Microtubules
negatively regulate insulin secretion in pancreatic β cells. Developmental Cell 34:656,
2015 PMCID: PMC4594944
120. Damond N, Thorel F, Moyers JS, Charron MJ, Vuguin PM, Powers AC, Herrera PL.
Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-
cells. eLife, pii: e13828. doi: 10.7554/eLife.13828 PMCID: PMC4871705
121. Atkinson MA, von Herrath M, Powers AC, Clare-Salzler M. Current Concepts on the
Pathogenesis of Type 1 Diabetes – Considerations for Attempts to Prevent and Reverse
the Disease,
Diabetes Care 38: 97, 2015 PMCID: PMC4439528
122. Raum J, Soleimanpour S, Groff D, Core N, Fasano L, Garratt A, Dai C, Powers AC,
Stoffers D. Tshz1 regulates pancreatic beta cell maturation. Diabetes 64:2905, 2015
PMCID: PMC4512227
123. Li M, Dean D, Zhao, L, Nicholson W, Powers AC, Chen W. A
Glucagon receptor
inactivation leads to α-cell hyperplasia in zebrafish, Journal of Endocrinology 227:93, 2015
PMCID: PMC4598637
124. Pan FC, Brissova M, Powers AC, Ptaff S, Wright CV. Inactivating the permanent neonatal
diabetes gene Mnx1 switches insulin-producing beta cells to a delta-like fate and reveals a
facultative proliferative capacity in aged beta cells. Development 142:3637, 2015 PMCID:
PMC4647212
125. Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C,
Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD,
Stein R
, Powers AC. In vivo metabolic stress impairs islet transcription factor expression
and insulin secretion in human islets. Journal of Clinical Investigation 126:1857, 2016
PMCID: PMC4855919
126.
Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Kumar N, Elso CM,
Armstrong M, Powell RL, Reisdorph N, DeNicola M, Bottino R, Powers AC, Harlan DM,
Kent SC, Mannering SI, Haskins K. Pathogenic CD4 T cells in type 1 diabetes recognize
epitopes formed by peptide fusion. Science 352:711, 2016 PMCID: PMC4884646
127. Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Granit RZ,
Condiotti R, Nevo Y, Fixler Y, Szoke T, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai
C, Glaser B, Powers AC, Scharfmann R, Shapiro AMJ, Magnuson MA, Dor Y, Ben-Porath
I. p16Ink4a-induced senescence of pancreatic β-cells enhances insulin secretion. Nature
Medicine, 22:412, 2016 PMCID: PMC5140746
128. Aamodt KI, Aramandla A, Brown J, Fiaschi-Taesch N, Wang P, Stewart AF, Marcela
Brissova, Powers AC. Development of a reliable, automated screening system to identify
small molecules and biologics that promote human β cell regeneration. American Journal
of Physiology - Endocrinology and Metabolism 311(5):E859, 2016 PMCID: PMC5130356
129. Arda HE, Lingyu L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K,
Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang
HY, Kim SK. Age-dependent pancreatic gene expression reveals regulators of human β-
cell function. Cell Metabolism 23:909, 2016 PMCID: PMC4864151
Alvin Carter Powers, MD, Curriculum Vitae - Page 24
130. Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Levy SE, Greiner DL,
Shultz LD, Bottino R, Kim SK, Powers AC. Age-dependent human β-cell proliferation
induced by GLP-1 and calcineurin signaling. Journal of Clinical Investigation 127:3835,
2017 PMCID: PMC5617654
131.
Powers AC, Wexler JA, Lash RW, Dyer MC, Becker MN, Vigersky RA. Affordable care act
implementation: challenges and opportunities to impact patients with diabetes. J Clin
Endocrinol Metab 101:1315, 2016 PMCID: PMC5399518
132. Saunders D, Powers AC. Replicative capacity of β-cells and type 1 diabetes. J of
Autoimmunity, 71:59, 2016 PMCID: PMC4903931
133. Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang J, McGuinness
OP, Powers AC, O’Brien RM. G6PC2 Modulates Fasting Blood Glucose in Response to
Stress. Endocrinology, 157:3002, 2016 PMCID: PMC4967123
134. Virostko J, Hilmes M, Eite MK, Moore DJ, Powers AC. Use of the Electronic Medical
Record to Assess Pancreas Size in Type 1 Diabetes. PLoS One 11:e0158825, 2016
PMCID: PMC4938534
135. Babon JA,DeNicola M, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji
A, Kaddis J, Elyaman W, James E, Haliyur R, Brissova M, Overbergh L, Mathieu C,
Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA,
Powers AC, Harlan DM, Kent SC. T Cells of Multiple Autoreactivities from Islets of Donors
with Type 1 Diabetes. Nature Medicine 22(12):1482, 2016 PMCID: PMC5140746
136. Ziegler AG, Bonifacio E, Powers AC, Todd J, Harrison L, Atkinson MA. Type 1 Diabetes
Prevention – A Goal Dependent on Accepting a Diagnosis of Asymptomatic Disease.
Diabetes
65:3233, 2016 PMCID: PMC5860440
137. Wang YJ, Golson ML, Schug J, Traum D, Chengyang Liu C, Vivek K, Dorrell C, Naji A,
Powers AC, Chang KM, Grompe M, Kaestner KH. Single-cell mass cytometry analysis of
the human endocrine pancreas. Cell Metabolism 24:616, 2016 PMCID: PMC5123805
138. Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A,
Sedgeman LR, Bozadjieva B, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich
MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy S, Dai
C, Gu W, Newgard C, Stein R, Chen W, Powers AC. Interrupted Glucagon Signaling
Reveals a Hepatic-α-Cell Axis and a Role for L-Glutamine in Stimulating α-Cell
Proliferation, Cell Metabolism 25:1362, 2017
PMCID: PMC5572896
139.
Marre ML, McGinty, JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino
R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA. Modifying enzymes
are elicited by ER stress, generating epitopes that are selectively recognized by CD4+ T
cells in patients with type 1 diabetes.
Diabetes 67:1356-1368, 2018 PMCID: PMC6014552
140.
Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok
M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA. Rebranding
asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a
pathological and diagnostic entity. Diabetologia 60:35, 2017 PMCID: PMC5516264
141. Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty
H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In't Veld PA. Re-
addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1
diabetes: is change necessary? (Letter to Editor). Diabetologia 60:753, 2017 PMCID:
PMC5415083
142. Aamodt KI, Powers, AC. Signals in the pancreatic islet microenvironment influence β cell
proliferation. Diabetes, Obesity and Metabolism 19 (Suppl 1):124, 2017 PMCID:
PMC5679109
143. Westacott MJ, Farnsworth NL, St. Claira JR, Poffenberger G, Heintz A, Ludin NL, Hart NJ,
Powers AC, Benninger RKP. Age-dependent decline in the coordinated [Ca2+] and insulin
Alvin Carter Powers, MD, Curriculum Vitae - Page 25
secretory response in human pancreatic islets, Diabetes 66:2436. 2017 PMCID:
PMC5566297
144. Brissova
M, Haliyur R, Saunders D, Shrestha S, Dai
C, Blodgett
DM, Bottino
R, Campbell-
Thompson
M, Aramandla
R, Poffenberger
G, Lindner J, Pan
FC, von Herrath
MG, Greiner
DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson
MA, Harlan
DM, Levy SE, Prasad N,
Stein
R, Powers AC. α Cell Function and Gene Expression Are Compromised in Type 1
Diabetes. Cell Reports 22:2667, 2018 PMCID: PMC6368357
145. Cogger KF, Sinha A, Sarangi F, McGaugh E, Saunders D, Dorrell C, Mejia-Guerrero S,
Aghazadeh Y, Rourke JL, Screaton RA, Grompe M, Streeter PR, Powers AC, Brissova M,
Kislinger T, Nostro MC. Glycoprotein 2 is a specific cell surface marker of human
pancreatic progenitors. Nature Communications 8:331, 2017 PMCID: PMC5569081
146.
Sui L, Danzl N, Campbell SR, Viola R, Williams D, Xing Y, Wang Y, Phillips N,
Poffenberger G, Johannesson B, Oberholzer J, Powers AC, Leibel RL, Chen X, Sykes M,
Egli D. Beta Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer
Embryonic Stem Cells. Diabetes 67:26, 2018 PMCID: PMC5741143
147. Bogdani M, Blackman SM, Ridaura C, Bellocq J, Powers AC, Aguilar-Bryan L Structural
abnormalities in islets from very young children with cystic fibrosis may contribute to cystic
fibrosis-related diabetes. Scientific Reports 7:17231, 2017 PMCID: PMC5722914
148. Conway BN, Han X, Munro HM, Gross AL, Shu XO, Hargreaves MK, Zheng W, Powers
AC, Blot WJ. The obesity epidemic and rising diabetes incidence in a low-income racially
diverse Southern US cohort, PLoS One 13:e0190993, 2018 PMCID: PMC5764338
149. Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Austin Bautista A,
Spigelman AF, Babon JA, DeNicola ME, Dadi PK, Bush WE, Balamurugan AN, Brissova
M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE,
Powers AC. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI
Insight 3: e98240, 2018 PMCID: PMC5931120
150.
Abbruzzese JL, Andersen DK, Borrebaeck CA, Chari ST, Costello E, Cruz-Monserrate Z,
Eibl G, Engleman EG, Fisher WE, Habtezion A, Kim SK, Korc M, Logsdon C, Lyssiotis CA,
Pandol SJ, Rustgi A, Wolfe BM, Zheng L, Powers AC. The interface of pancreatic cancer
with diabetes, obesity and inflammation: research gaps and opportunities – summary of a
national institute of diabetes and digestive and kidney diseases workshop. Pancreas
47:516, 2018 PMCID: PMC6361376
151.
Cefalu WT, Dawes DE, Gavlak G, Goldman D, Herman WH, Van Nuys K, Powers AC,
Taylor SI, Yatvin AL. Insulin Access and Affordability Working Group: Conclusions and
Recommendations. Diabetes Care
41:1299, 2018 PMCID: pending
152. Syring
KE, Bosma
KJ, Oeser
JK, Dai
C, Poffenberger
G, Shiota
M, Powers
AC,
McGuinness
OP, Powell
DR, O’Brien RM. Slc30a8 Haploinsufficiency Protects Against
Diet-Induced Obesity in Male Mice. Submitted
153.
Russell MA, Redick SD, Blodgett DB, Richardson SJ, Vendrame F, Burke GB, Pugliese A,
Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, Haliyur R, Powers AC,
Yang C, Kent SC, Derr A, Kucukural A, Garber MG, Morgan NG, Harlan DM. HLA Class II
antigen processing and presentation pathway components demonstrated by transcriptome
and protein analyses of islet β cells from donors with type 1 diabetes. Diabetes, in press,
2019
154. Hart, NJ, Powers, AC. Progress, challenges, and suggestions for using human islets to
understand islet biology and human diabetes. Diabetologia 62:212-222, 2019 PMCID:
PMC6325002
155.
Horwitz E, Krogvold L, Zhitomirsky S, Swisa A, Fischman M, Lax T, Dahan T, Hurvitz N,
Weinberg-Corem N, Klochendler A, Powers AC, Brissova M, Jörns A, Lenzen S, Glaser B,
Dahl-Jørgensen K, Dor Y. Beta Cell DNA Damage Response Promotes Islet Inflammation
in Type 1 Diabetes. Diabetes 67:2305-2318 PMCID: PMC6198335
Alvin Carter Powers, MD, Curriculum Vitae - Page 26
156. Wright JJ, Salem JE, Johnson DB, Lebrun-Vignes B, Stamatouli A, Thomas JW, Herold
KC, Moslehi J, Powers AC. Increased Reporting of Immune Checkpoint Inhibitor-
Associated Diabetes Mellitus. Diabetes Care 41:e150, 2018 doi: 10.2337/dc18-1465
157. Haliyur R, Tong X, Sanyoura M, Shrestha S, Lindner J, Saunders D, Aramandla R,
Poffenberger G, Redick SD, Bottino R, Prasad N, Levy SE, Blind RD, Harlan DM,
Philipson LH, Stein R, Brissova M, Powers AC. HNF1A variant Impacts β cell Glucose
Responsiveness Causing Insulin-Insufficient Diabetes. Journal of Clinical Investigation
129:246-251, 2019 PMCID: PMC6307934
158. Virostko J*, Williams J, Hilmes M, Bowman C, Wright JW, Du L, Kang H, Russell WE,
Powers AC*, Moore DJ* (*corresponding authors)
. Pancreas Volume Declines During the
First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease
Onset. Diabetes Care 42:248-257, 2019 PMCID: PMC6341292
159. Cyphert HA, Walker EM, Hang Y, Dhawan S, Haliyur R, Bonatakis L, Avrahami D,
Brissova M, Kaestner KH, Bhushan A, Powers AC, Stein R. Examining How the MAFB
Transcription Factor Affects Islet β Cell Function Postnatally Diabetes. 68:337-348, 2019
PMCID: PMC6341297
160. Saunders D, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger
G, Flaherty DK, Weller KP, Pelletier J, Cooper C, Gofff MT, Virostko J, Shostak A, Dean
ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers
AC. NTPDase3 antibody targets adult human pancreatic β-cells for in vitro and in vivo
analysis. Cell Metabolism 29:745-754, 2019 PMCID: PMC6402969
161. Wang YJ, Traum D, Schug J, Gao L, Liu C, Atkinson MA, Powers AC, Feldman MD, Naji
A, Chang KM, Kaestner KH. Multiplexed in situ imaging mass cytometry analysis of the
human endocrine pancreas and immune system in type 1 diabetes. Cell Metabolism
29(3):769-783, 2019 PMCID: pending
162. Engelhardt BE, Savani U, Jung DK, Powers AC, Jagasia M, Chen H, Winnick JJ, Tamboli
RA, Crowe JE, Abumrad NN. New-onset post-transplant diabetes mellitus after allogeneic
hematopoietic cell transplant is initiated by insulin resistance, not immunosuppressive
medications. Biology of Blood and Marrow Transplantation, in press
163. Prentice BM, Hart NJ, Phillips N, Haliyur R, Judd A, Armandala R, Spraggins JM, Lowe
CL, Boyd KL, Stein RW, Wright CV, Norris JL, Powers AC, Brissova M, Caprioli RM.
Imaging Mass Spectrometry Enables Molecular Profiling of Mouse and Human Pancreatic
Tissue. Diabetologia, in press
164. Elsakr JM, Dunn JC, Tennant K, Zhao SK, Kroeten K, Pasek RC, Takahashi DL, Dean TA,
Velez Edwards DR, McCurdy CE, Aagaard KM, Powers AC, Friedman JE, Kievit P,
Gannon M. Maternal Western-style diet affects offspring islet composition and function in a
non-human primate model of maternal over-nutrition. Molecular Metabolism, in press
Books and Book Chapters:
1. Eisenbarth GS, Jackson R, Srikanta S, Powers A, Buse J, Mori H. Utilization of
Monoclonal Antibody Techniques to Study Type I (Insulin-dependent) Diabetes Mellitus.
Immunology in Diabetes, Kimpton Medical Publishing, 1984.
2. Thomas JW, Powers AC. “Immunology of Diabetes” in Clinical Immunology: Principles
and Practices. Mosby-Year Book, Inc, 1995.
3. Powers AC. “Diabetes Mellitus” in Harrison’s Principles of Internal Medicine, 15th Edition,
Editors, Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, McGraw
Hill, New York, NY, 2001.
Alvin Carter Powers, MD, Curriculum Vitae - Page 27
4. Powers AC. “Diabetes Mellitus” in Harrison’s Principles of Internal Medicine, 16th Edition,
Editors, Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, McGraw
Hill, New York, NY, 2004.
5. Brissova M, Powers AC. “Architecture of Pancreatic Islets” in Pancreatic Beta Cell in
Health and Disease. Editors, Seino S, Bell GI, Springer-Verlag Toyko, 2008.
6. Powers AC. “Diabetes Mellitus” in Harrison’s Principles of Internal Medicine, 17th Edition,
Editors, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo
J, McGraw Hill, New York, NY, 2008.
7. Powers AC and Ahima RS, Editors, The Year in Diabetes and Obesity, Annals of the New
York Academy of Sciences, 2010
8. Powers AC and D’Alessio D. “Pharmacology of the Endocrine Pancreas” in Goodman &
Gilman's The Pharmacological Basis of Therapeutics, 12
th
Edition, Editor, Laurence L.
Brunton, McGraw Hill, New York NY, 2011
9. Powers AC. “Diabetes Mellitus” in Harrison’s Principles of Internal Medicine, 18th Edition,
Editors, Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, McGraw
Hill, New York, NY, 2011
10. Powers AC. Guest Editor of Translational Endocrinology and Metabolism: Type 2 Diabetes
Update, Editor-in-Chief, Robertson, RP, The Endocrine Society Publications, Chevy
Chase, MD, 2011
11. Powers AC and Stein R. “New Insights of Islet Biology and the Pathophysiology of Type 2
Diabetes” in Translational Endocrinology and Metabolism: Type 2 Diabetes Update,
Editor-in-Chief, Robertson, RP, The Endocrine Society Publications, Chevy Chase, MD,
2011
12. Greiner DL Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD. Humanized Mice for
the Study of Type 1 and Type 2 Diabetes. Annals of the New York Academy of Sciences
1245:55, 2011 PMCID: PMC3384500
13. Ahima RS and Powers AC, Editors, The Year in Diabetes and Obesity, Annals of the New
York Academy of Sciences, 2011
14. Brehm M, Powers AC, Shultz LD, Greiner DL. Advancing Animal Models of Human Type 1
Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice.
Perspectives on Type 1 Diabetes, Editors: Jeffrey A. Bluestone, Mark A. Atkinson, and
Peter R. Arvan Editors: Jeffrey A. Bluestone, Mark A. Atkinson, and Peter R. Arvan. Cold
Spring Harbor Laboratory Press, 2012 May;2(5):a007757, PMCID: PMC3331686
15. Powers AC and Ahima RS, Editors, The Year in Diabetes and Obesity, Annals of the New
York Academy of Sciences, 2013
16. Nyman LR, Brissova M, Powers AC. “Opportunities for Improving the Revascularization of
Transplanted Islets”, Islets: Biology, Immunology, and Clinical Transplantation, Editor,
Kandell F., Springer, 2013
17. Ahima RS and Powers AC, Editors, The Year in Diabetes and Obesity, Annals of the New
York Academy of Sciences, 2013
18. Powers AC, “Architecture and Morphology of Human,” in Cellular Endocrinology in Health
and Disease, Editors, Alfredo Ulloa-Aguirre and P. Michael Conn, Academic Press /
Elsevier, Inc., 2013
19. Ahima RS and Powers AC, Editors, The Year in Diabetes and Obesity, Annals of the New
York Academy of Sciences, 2014
20. Powers AC. “Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology” in
Harrison’s Principles of Internal Medicine, 19th Edition, Editors, Kasper DL, Fauci AS,
Longo DL, Hauser SL, Jameson JL, Loscalzo J. McGraw Hill, New York, NY, 2015
Alvin Carter Powers, MD, Curriculum Vitae - Page 28
21. Powers AC. “Diabetes Mellitus: Management and Therapies” in Harrison’s Principles of
Internal Medicine, 19th Edition, Editors, Kasper DL, Fauci AS, Longo DL, Hauser SL,
Jameson JL, Loscalzo J. McGraw Hill, New York, NY, 2015
22. Powers AC. “Diabetes Mellitus: Complications” in Harrison’s Principles of Internal
Medicine, 19th Edition, Editors, Kasper DL, Fauci AS, Longo DL, Hauser SL, Jameson JL,
Loscalzo J. McGraw Hill, New York, NY, 2015
23. Ahima RS and Powers AC, Editors, The Year in Diabetes and Obesity, Annals of the New
York Academy of Sciences, 2015
24. Powers AC and D’Alessio D. “Pharmacology of the Endocrine Pancreas” in Goodman &
Gilman's The Pharmacological Basis of Therapeutics, 13
th
Edition, Editor, Laurence L.
Brunton, McGraw Hill, New York NY, 2017
25. Powers AC, KD Niswender, Carmella Evans- Molina. “Diabetes Mellitus: Diagnosis,
Classification, and Pathophysiology” in Harrison’s Principles of Internal Medicine, 20th
Edition, Editors, Kasper DL, Fauci AS, Longo DL, Hauser SL, Jameson JL, Loscalzo J.
McGraw Hill, New York, NY, 2018
26. Powers AC, KD Niswneder, MR Rickles. “Diabetes Mellitus: Management and Therapies”
in Harrison’s Principles of Internal Medicine, 20th Edition, Editors, Kasper DL, Fauci AS,
Longo DL, Hauser SL, Jameson JL, Loscalzo J. McGraw Hill, New York, NY, 2018
27. Powers AC, JM Stafford, MRl Rickles. “Diabetes Mellitus: Complications” in Harrison’s
Principles of Internal Medicine, 20th Edition, Editors, Kasper DL, Fauci AS, Longo DL,
Hauser SL, Jameson JL, Loscalzo J. McGraw Hill, New York, NY, 2018
Presentations (invited):
1990 “Molecular and Immunologic Mechanisms of Grave’s Disease”, Medical Grand Rounds,
Vanderbilt University School of Medicine, Nashville, TN
1991 “Estrogen Replacement in the Post-menopausal Woman”, Medical Grand Rounds,
Vanderbilt University School of Medicine, Nashville, TN
1992 “Interpretation of Thyroid Function Tests”, Ninth Annual Family Medicine Primary Care
Update, Vanderbilt University Medical Center, Nashville, Tennessee
1994 “Prediction and Prevention of Type I Diabetes”, Medical Grand Rounds, Vanderbilt
University School of Medicine, Nashville, TN
1994 “Ret Oncogene and MEN 2”, Endocrine Grand Rounds, Vanderbilt University School of
Medicine, Nashville, TN
1995 “Update on Diabetes”, Juvenile Diabetes Foundation, Inc., Nashville Chapter
1996 “Design of Immunoisolation Devices for the Treatment of Diabetes”, Seminar in Applied
Physics, Vanderbilt University, Nashville, Tennessee
1996 “Encapsulated Islets as a Treatment for Diabetes”, American Association for Laboratory
Animal Science, Appalachian Branch Spring Meeting, Nashville, Tennessee
1996 “Permeability Optimization of Immunoisolation Devices”, Bioartifical Organs: Science
and Technology, Engineering Foundation Conferences, Nashville, Tennessee
1997 “Screening and Treatment of Thyroid Disease”, Fourteenth Annual Family Medicine
Primary Care Update, Vanderbilt University Medical Center, Nashville, Tennessee
1998 “Nuclear Fallout, Radiation, and Thyroid Cancer”, Endocrine Grand Rounds, Vanderbilt
University School of Medicine, Nashville, TN
1998 “Iodide, Amiodarone, Nuclear Fallout, and the Thyroid”, Medical Grand Rounds,
Vanderbilt University School of Medicine, Nashville, TN
1998 “Recent Advances in Islet Encapsulation”, 5th International Meeting on the Genetics,
Pathogenesis, Prevention, and Therapy of Type I Diabetes, Erice, Italy
Alvin Carter Powers, MD, Curriculum Vitae - Page 29
1999 “Microencapsulation of Islets for Xenotransplantation”, Transplantation Research Day,
Vanderbilt University
1999 “Thiazolidinediones: Target, Therapy, and Toxicity”, Endocrine Grand Rounds,
Vanderbilt University School of Medicine, Nashville, TN
2000 “Role of Pdx-1 in Glucose-Stimulated Insulin Secretion”, Metabolex, Inc., Hayward, CA
2000 “Type 2 Diabetes: Current Therapy”, Annual Conference of Tennessee Nurse
Practitioners, Nashville, TN
2000 “Diabetes-how many types are there?”, Endocrine Grand Rounds, Vanderbilt University
School of Medicine, Nashville, TN
2000 “Diabetes-research update”, Juvenile Diabetes Research Foundation International,
Mississippi Chapter, Jackson, MS
2000 “Role of Pdx-1 in Maintenance of Glucose-Stimulated Insulin Secretion”, City-Wide
Endocrine Conference, University of Minnesota, Minneapolis, MN
2000 “Diabetes-current and future classifications”, OSI Pharmaceuticals, Tarrytown, NY
2001 “Diabetes-how many types are there?”, Department of Medicine Seminar, Texas Tech
Health Sciences Center at El Paso, El Paso, TX
2001 “Role of Pdx-1 in Maintenance of Glucose-Stimulated Insulin Secretion”, Endocrine
Conference, University of Tennessee Center for Health Sciences, Memphis, TN
2001 “Role of Pdx-1 in Maintenance of Glucose-Stimulated Insulin Secretion”, Research
Endocrinology Conference, University of Pittsburgh, Pittsburgh, PA
2001 “Role of Pdx-1 in Maintenance of Glucose-Stimulated Insulin Secretion”, Transplant
Grand Rounds, NIDDK/Navy Autoimmunity and Transplantation Branch, Bethesda, MD
2001 “Role of Pdx-1 in “Glucose-Stimulated Insulin Secretion”, Department of Medicine
Seminar, University of Oklahoma Health Sciences Center, Oklahoma City, OK
2001 “Evolution of Islet Cell Transplantation as a Treatment for Type 1 Diabetes, at Nursing
Management of Diabetes 2001, St. Thomas Health Services, Nashville, TN
2001 “Biologic Replacement of Insulin”, Endocrine Grand Rounds, Vanderbilt University
School of Medicine, Nashville, TN
2002 “Biologic Replacement of Insulin-how close or how far?”, Endocrine Grand Rounds,
National Institute of Health, Bethesda, MD
2002 "Pancreatic Islet Transplantation-is it ready for prime time?", 17th Annual Diabetes
Mellitus Conference of Middle Tennessee Association of Diabetes Educators, Nashville,
TN
2002 Clinical Endocrinology Update - Board Review organized by The Endocrine Society,
"Diabetes Mellitus", Portland, OR
2002 "Diabetes Mellitus; Clinical Aspects and Unanswered Questions", Department Seminar,
Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN
2002 “Update on Thyroid Disease”, Student Health Services, Vanderbilt University, Nashville,
TN
2003 “GLP-1 in Type 2 Diabetes: more than an insulin secretagogue”, Endocrinology Grand
Rounds, Vanderbilt University Medical Center, Nashville, TN
2003 “Pancreatic Islet Transplantation: Challenges and Opportunities”, Endocrinology State-
of-the Art Presentation, Southern Society of Clinical Investigation, New Orleans, LA
2003 “Using Bioluminescence to Non-invasively Image and Assess Transplanted Islet Mass”,
National Institutes of Health Workshop on “Imaging the Pancreatic Beta Cell”,
sponsored by National Institute of Biomedical Imaging, National Institute of Diabetes
and Digestive and Kidney Diseases, Juvenile Diabetes Research Foundation,
Bethesda, MD
2003 “Vascularization and Revascularization of Pancreatic Islets”, Endocrinology Grand
Rounds, Indiana University Medical Center, Indianapolis, IN
Alvin Carter Powers, MD, Curriculum Vitae - Page 30
2003 “Vascularization and Revascularization of Pancreatic Islets”, Rheumatology Research
Seminar, Vanderbilt University Medical Center, Nashville, TN
2003 Clinical Endocrinology Update - Board Review organized by The Endocrine Society,
"Diabetes Mellitus and Obesity", Miami, FL
2003 “Vascularization and Revascularization of Pancreatic Islets”, Endocrinology Grand
Rounds, University of Miami Medical Center, Miami, FL
2003 “Imaging and Revascularization of Pancreatic Islets”, 3
rd
Annual Symposium on Islet
Transplantation, Rancho Mirage, CA
2004 “Pancreatic Islet Transplantation: Challenges and Obstacles”, National Board of
Directors of Juvenile Diabetes Research Foundation, International, Nashville, TN
2004 “Pancreatic Islets: Vascularization and Revascularization”, Research Seminar,
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville,
TN
2004 “Pancreatic Islets: Vascularization and Revascularization”, Diabetes Seminar, University
of Pennsylvania, Philadelphia, PA
2004 “Pancreatic Islets: Vascularization and Revascularization”, Endocrinology Grand
Rounds, Northwestern University School of Medicine, Chicago, IL
2004 Invited Session Chair, NIH Workshop, “Immunobarriers for Pancreatic Islet
Transplantation”, Washington, D.C.
2004 Research Update, Juvenile Diabetes Research Foundation, International, Nashville
Chapter, Nashville, TN.
2004 Clinical Endocrinology Update - Board Review organized by The Endocrine Society,
"Diabetes Mellitus and Obesity", Baltimore, MD
2004 “Survival, Function, and Sustenance of Pancreatic Islets: What Do We Know and What
Do We Need to Know”, NIH Beta Cell Biology Consortium Investigator Retreat,
Chicago, IL
2004 “Diabetes Mellitus: Diagnosis, Treatment, and Monitoring”, American Society for Clinical
Laboratory Sciences, Region III, Nashville, TN
2004 “Vascularization of Pancreatic Islets and the Revascularization of Transplanted Islets”,
5
th
Annual Rachmiel Levine Diabetes and Obesity Symposium, Los Angeles, CA
2004 “Pathogenesis of Type 2 Diabetes: Focus on the Beta Cell”, Endocrinology Grand
Rounds, Vanderbilt University Medical Center, Nashville, TN
2004 Question and Comment Panel, “Islet Cell Transplant, Prelude to the Future”,
Philadelphia, PA
2005 “Pancreatic Islets: Vascularization and Revascularization”, Renal Research Seminar,
Vanderbilt University, Nashville, TN
2005 “In vivo imaging of pancreatic islets”, American Diabetes Association annual meeting,
San Diego, CA
2005 “Bioluminescent imaging of transplanted pancreatic islets”, Islet Cell Resource Centers,
Islet Workshop Meeting, Duarte, CA
2005 “Pancreatic Islets: Vascularization and Revascularization”, Endocrine Grand Rounds,
Section of Endocrinology, University of Chicago, Chicago, IL
2005 Clinical Endocrinology Update - Board Review organized by The Endocrine Society,
"Diabetes Mellitus", Toronto, Canada
2005 “Molecular Events of Islet Transplantation: What Do We Know and What Do We Need to
Know”, Immunology of Diabetes (8
th
annual meeting), Osaka, Japan
2005 “Update on Research to Prevent and Cure Type 1 Diabetes”, Diabetes Family Day,
Vanderbilt University Medical Center, Nashville, TN
2006 “Islet Transplantation: Current State and Future Directions”, Nephrology Grand Rounds,
Vanderbilt University Medical Center, Nashville, TN
Alvin Carter Powers, MD, Curriculum Vitae - Page 31
2006 “Pancreatic islet vascularization and revascularization”, Keystone Symposium,
“Pancreatic Islets: From Development to Transplantation”, Taos, NM
2006 “Assessment of pancreatic mass by bioluminescence”, NIH workshop, Imaging the
Pancreatic Beta Cell in Health and Disease, 3
rd
workshop, Washington, D.C.
2006 “Pancreatic Islet Imaging”, Eli Lilly and Company, Indianapolis, IN
2006 “Islet Cell Transplantation as a Model to Study Beta Cell Regeneration”, American
Diabetes Association annual meeting, Boston, MA
2006 “Islet Transplantation as a Model to Study β Cell Regeneration”, International College of
Surgeons, United States Section, Nashville, TN
2006 Clinical Endocrinology Update - Board Review organized by The Endocrine Society,
"Diabetes Mellitus", San Francisco, CA
2006 “Imaging Pancreatic Islets with Bioluminescence”, Workshop on New Bioimaging
Techniques for Small Animals, University of Geneva, Geneva, Switzerland
2006 “Pancreatic Islets: Vascularization and Revascularization”, Frontiers in Biology Seminar,
University of Geneva, Geneva, Switzerland
2006 “Improvements in Pancreatic Islet Revascularization”, 7
th
Annual Rachmiel Levine
Diabetes and Obesity Symposium, Los Angeles, CA
2006 “Non-invasive Imaging of Pancreatic Islets”, Vanderbilt University Institute for Imaging
Sciences, Nashville, TN
2007 “Pancreatic Islets: Vascularization and Revascularization”, Lawson Health Research
Institute Seminar, London, Ontario
2007 “Future Directions in Measuring Beta-cell Mass and Function”, American Diabetes
Association Research Symposium: Translating Islet Biology into Diabetes Therapy,
Stone Mountain, GA
2007 “Pancreatic Islets: Vascularization and Revascularization”, Research Seminar, Rolf Luft
Center for Diabetes and Endocrinology, Karolinska Institutet
2007 “Pancreatic Islet Imaging: What do we want to know and how do we measure it?”, State
of the Art Lecture, American Diabetes Association annual meeting, Chicago, IL
2007 “Update on Research Related to Type 1 Diabetes”, Middle Tennessee Chapter of
Juvenile Diabetes Research Foundation, Nashville, TN
2007 Clinical Endocrinology Update - Board Review organized by The Endocrine Society,
"Diabetes Mellitus", San Antonio, TX
2007 “Pancreatic Islet Imaging: What do we want to know and how do we measure it?” Annual
Meeting of Korean Diabetes Association, Pusan, South Korea
2007 “Imaging of Islet Cells: Application to Islet and Pancreas Transplantation”, Global
Diabetes Summit, “Conquering Diabetes Frontiers with New Discoveries and
Technologies”, Ohio State University, Columbus, Ohio
2007 “Update on Research Related to Type 1 Diabetes”, Pediatric Diabetes Family Day,
Vanderbilt University Medical Center
2007 “Pancreatic Islets: Vascularization, Revascularization, and Regeneration”, Endocrine
Grand Rounds, University of Texas Southwestern Medical Center
2008 “Insulin Therapy versus Cell Therapy for Type 1 Diabetes: What about the future?” 9
th
Annual Rachmiel Levine Diabetes and Obesity Symposium, Los Angeles, CA
2008 “Pancreatic Islets: Vascularization, Revascularization, and Regeneration”, Endocrine
Grand Rounds, University of Pittsburgh Medical Center, Pittsburgh, PA
2008 “Pancreatic Islets: Vascularization, Revascularization, and Regeneration”, Barbara Davis
Diabetes Center, University of Colorado Medical Center, Denver, CO
2008 “Pancreatic Islets: Vascularization, Revascularization, and Regeneration”, Endocrine
Grand Rounds, National Institutes of Health, NIDDK, Bethesda, MD
Alvin Carter Powers, MD, Curriculum Vitae - Page 32
2008 “Islet-Enriched Transcription Factors, Vascularization, and Insulin Secretion”, National
Institute of Diabetes and Digestive and Kidney Diseases Workshop, Diabetes Genes
and Beta Cell Function: How Can We Assemble the Puzzle?, Bethesda, MD
2008 “How Do We Improve Islet Revascularization After Transplantation?”, American
Diabetes Association annual meeting, San Francisco, CA
2008 “Imaging Approaches to Follow Islets In Vivo”, Keystone Symposium, “Islet and Beta
Cell Development and Transplantation”, Snowbird, UT
2008 “Update on Research Related to Type 1 Diabetes”, Middle Tennessee Chapter of
Juvenile Diabetes Research Foundation, Nashville, TN
2008 Clinical Endocrinology Update - Board Review organized by The Endocrine Society,
"Diabetes Mellitus", Boston, MA
2008 “Research Related to Type 1 Diabetes”, Pediatric Diabetes Family Day, Vanderbilt
University Medical Center
2008 “GLP-1 Signaling and Islet Transplantation”, 2
nd
Annual National Symposium on
Incretion Biology, Toronto, Canada
2009 “Pancreatic Islets: Vascularization, Innervation, and Regeneration”, Department of
Biochemistry, University of Wisconsin, Madison, WI
2009 “Pancreatic Islets: Vascularization, Innervation, and Regeneration”, Department of
Nutrition, Duke University, Durham, NC
2009 “Pancreatic Islets: Vascularization, Innervation, and Regeneration”, DRTC Seminar,
Albert Einstein College of Medicine, Bronx, NY
2009 “Pancreatic Islets: Vascularization, Innervation, and Regeneration”, Pacific Northwest
Diabetes Research Institute Seminar, Seattle, WA
2009 “Pancreatic Islets: Vascularization, Revascularization, and Regeneration”, Imaging the
Pancreatic Beta Cell, Fourth Workshop, April 6-7, 2009, Washington, D.C.
2009 “Challenges and Opportunities for Imaging in Diabetes”, Frontiers of Biomedical Imaging
Science, June 2-5, 2009 Vanderbilt University Institute of Imaging Science, Nashville,
Tennessee
2009 “Mouse and Human Islets in Type 1 Diabetes – Similarities and Differences”, American
Diabetes Association annual meeting, New Orleans, LA
2009 “Opportunities and Challenges for Imaging Pancreatic Islets”, Eli Lilly, Indianapolis, IN
2009 Clinical Endocrinology Update - Board Review organized by The Endocrine Society,
"Diabetes Mellitus", Atlanta, GA
2009 "Human Islet Biology", Juvenile Diabetes Research Foundation nPOD annual meeting,
Washington, D.C.
2010 "What is a pancreatic islet?" Juvenile Diabetes Research Foundation Islet Niche
Workshop, New York, NY
2010 “Pancreatic Islets: Vascularization, Innervation, and Regeneration”, Pediatric Diabetes
Research Center Opening Symposium, University of California San Diego, San Diego,
CA
2010 “Type 2 Diabetes: Pancreatic Islet Response to Insulin Resistance”, Hamamatsu
Medical School, Hamamatsu, Japan
2010 “Pancreatic Islets: Vascularization and Innervation”, Burnham Institute for Medical
Research, Lake Nona, Florida
2010 “Beta cell-replacement therapy for type 1 diabetes: where are we now and where are we
going?” Banting and Best Diabetes Center, University of Toronto, Toronto, Canada
2010 “Pancreatic Islets: Vascularization, Innervation, and Regeneration”, Islet Study Group of
European Association for Study of Diabetes, Tallberg, Sweden
2010 “Pancreatic Islets: Vascularization, Innervation, and Regeneration”, Translational Biology
and Molecular Medicine Graduate Program Seminar Series, Baylor College of
Medicine, Houston, TX
Alvin Carter Powers, MD, Curriculum Vitae - Page 33
2011 “Pharmacologic or cell-based therapy for type 1 diabetes – where are we now and where
are we going?”, Kroc Lectureship, Division of Diabetes, Endocrinology & Metabolism,
Baylor College of Medicine, Houston, TX
2011 “Islet – Endothelial Cells Interactions: Role in Function and Proliferation?”, Charles
Hollenberg Lectureship, Banting and Best Diabetes Centre, University of Toronto,
Toronto, Canada
2011 “Islets and Endothelial Cells: Context and Connections?” Diabetes Day, University of
Chicago, Chicago, IL
2011 “Islets and Endothelial Cells: Context and Connections?” 93
rd
Annual Meeting of The
Endocrine Society, Boston, MA
2011 “Mouse and Human Islets: Context and Connections” JDRF-IDS Satellite Symposium at
the Annual Meeting of the Federation of Clinical Immunology Societies, ‘Type 1
Diabetes - Insulitis Revisited: Cross-Talk between the Immune System and the Beta
Cell’, Washington, DC
2011 “Islets and Endothelial Cells: Context and Connections” Satellite meeting of The Society
for Developmental Biology, ‘Translating Pancreatic Development to Treat Diabetes’,
Chicago, IL
2011 “Pancreas and Islet Transplantation,” Annual Clinical Endocrinology Update by The
Endocrine Society, Nashville, TN
2011 “Monogenic Diabetes and LADA,” Meet-the-Professor Sessions and the Annual Clinical
Endocrinology Update by The Endocrine Society, Nashville, TN
2011 “Islets and Endothelial Cells: Context and Connections,” World Diabetes Congress
organized by the International Diabetes Federation, Dubai, United Arab Emirates
2012 “Islets and Endothelial Cells: Context and Connections,” Vascular Biology Seminar
Series, Yale School of Medicine, New Haven, CT
2012 “Islets and Endothelial Cells: Context and Connections,” Kroc Lectureship, University of
Washington, Division of Diabetes and Endocrinology, Seattle, WA
2012 “Pharmacologic versus cell-mediated insulin replacement for diabetes – where are we
now and where are we going?” Annual Meeting of Endocrine Nurses Association at
Annual meeting of The Endocrine Society, Houston, TX
2012 “Human Islets: Context, Connections, and Considerations” at Indo US Science and
Technology Forum/Workshop on “Pancreatic Islets: From Isolation to Transplantation,”
Hyderabad, India
2012 “Islet Vascularization and Innervation – context and connections,” Centre for
Neuroscience, Flinders University, Adelaide, SA, Australia
2012 “Pancreatic Islet Vascularization and Innervation – context and connections,” Centre for
Cancer Biology, Adelaide, SA, Australia
2012 “Islet Vascularization and Innervation – context and connections,” 5
th
Annual Australian
Islet Study Group, Melbourne, VIC, Australia
2012 “Pancreatic Islet Vascularization and Regeneration: Endothelial Cells, Macrophages,
and β Cells,” St Vincent's Institute, Fitzroy, VIC, Australia
2012 “Pancreatic Islet Vascularization and Regeneration: Endothelial Cells, Macrophages,
and β Cells,” Research Seminar Series, Institute for Diabetes, Obesity, and
Metabolism, University of Pennsylvania, Philadelphia, PA
2013 “Pancreatic Islet Vascularization and Regeneration: Endothelial Cells, Macrophages,
and β Cells,” Molecular Medicine Research Seminar at Children's Hospital of
Pittsburgh, Pittsburgh, PA
2013 “Pharmacologic versus cell-mediated insulin replacement for diabetes – where are we
now and where are we going?" Endocrine Grand Rounds, University of Massachusetts,
Worcester, MA
Alvin Carter Powers, MD, Curriculum Vitae - Page 34
2013 “Type 1 Diabetes: current therapies versus emerging therapies using insulin-producing
cells,” 2013 Ray A. and Robert L. Kroc Lecturer in Diabetes and Endocrinology, Medical
Grand Rounds, University of Alabama Birmingham, Birmingham, AL
2013 “Imaging or Targeting the beta cell: context, connections, and considerations" Keynote
Speaker, NIH Workshop: Imaging the Pancreatic Beta Cell, 5
th
Workshop, Bethesda,
MD
2013 “Emerging Research Related to Type 1 and Type 2 Diabetes”, “28th Annual Clinical
Conference on Diabetes, American Diabetes Association, Orlando, FL
2013 “Management of diabetes in patients with CV disease,” The Best of ADAIndia, Kolkata,
India and Lucknow, India
2013 “Management of microalbuminuria and diabetic nephropathy,” The Best of ADAIndia,
Kolkata, India and Lucknow, India
2013 “Approaches to assess beta cell or islet cell mass: current status and future directions,”
World Diabetes Congress, Melbourne, Australia
2013 “β Cells, Endothelial Cells, and Macrophages Create Microenvironment that Promotes
Islet Regeneration,” 13th International Congress of the Immunology of Diabetes
Society, Lorne, Australia
2014 “β Cells, Endothelial Cells, and Macrophages and Islet Regeneration,” Montreal
Diabetes Research Centre, Montreal, Canada
2014 “Role of β cell in Type 1 and Type 2 Diabetes: With Comments on Current and Emerging
Therapies,” Plenary Lecture, International Clinical Update in Endocrinology 2014,
Hyderabad, India
2014 “New Thinking About the Pathogenesis of Type 1 Diabetes,” International Clinical
Update in Endocrinology 2014, Hyderabad, India
2014 “GLP-1 Pathway Modifying Drugs: What we know? What we do not know?” International
Clinical Update in Endocrinology 2014, Hyderabad, India
2014 “In-patient Diabetes Management,” Meet-the-Professor, International Clinical Update in
Endocrinology 2014, Hyderabad, India
2014 “Some Thoughts on β cells and Islets as Related to Type 1 Diabetes,” Plenary Lecture,
Network for Pancreatic Organ Donors with Diabetes (nPOD) Annual Meeting, Atlantic
Beach, FL
2014 “Some Thoughts on β cells and Islets in Humans,” 14th Annual Rachmiel Levine
Symposium, Pasadena, CA
2014 “β Cells – Context, Connections, and Microenvironment,” GNF-JDRF Diabetes Research
Symposium, Genomics Institute of the Novartis Research Foundation, San Diego, CA
2014 “Role of β cell in Type 1 and Type 2 Diabetes: With Comments on Current and Emerging
Therapies,” Endocrine Grand Rounds, Division of Endocrinology, Diabetes &
Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD
2014 “β cell in Type 1 and Type 2 Diabetes: Current and Emerging Therapies,” Plenary
Lecture, American Association of Clinical Endocrinology Annual Meeting, Las Vegas,
NV
2014 “β Cells – Context, Connections, and Microenvironment,” Metabolism, Endocrinology,
and Diabetes Research Conference, University of Michigan, Ann Arbor, MI
2014 “Macrophages in Islet Injury and Regeneration,” 74
th
Annual Meeting of American
Diabetes Association, San Francisco, CA
2014 “Natural History of Beta Cell Failure,” 16
th
International Congress of Endocrinology and
the 96
th
Annual Meeting of the Endocrine Society, Chicago, IL
2014 “The Year in Type 1 Diabetes,” 16
th
International Congress of Endocrinology and the 96
th
Annual Meeting of the Endocrine Society, Chicago, IL
2014 “Update on GLP-1-based Therapies ‒ Effects on Endocrine, Exocrine, and Other
Tissues” and “Diabetic Kidney Disease - What’s in the Current and Future Toolbox?“
Alvin Carter Powers, MD, Curriculum Vitae - Page 35
Best of ADA China (organized by American Diabetes Association), Beijing, China and
Chengdu, China
2014 “Type 1 Diabetes: Random (Almost) Thoughts,” Endocrine Grand Rounds, Division of
Endocrinology, Diabetes & Metabolism, Vanderbilt University School of Medicine,
Nashville, TN
2014 “β cells and Type 1 Diabetes: Insights into Islet Biology,” First Cleveland Clinic
Symposium on Beta Cell Therapy, Cleveland, OH
2015 “Macrophages, Endothelial Cells, and β Cell Regeneration,” Vanderbilt University
Vascular Biology Center Seminar Series, Nashville, TN
2015 “Macrophages, Endothelial Cells, and β Cell Regeneration,” University of Washington,
Diabetes Research Center Seminar Series, Seattle, WA
2015 “Macrophages, Endothelial Cells, and β Cell Regeneration,” University of Southern
California, Diabetes and Obesity Research Institute Annual Symposium, Los Angeles,
CA
2015 “Some Thoughts about β cells and Their Role in Type 1 and Type 2 Diabetes,” Ray A.
and Robert L. Kroc Lectureship in Diabetes at the Annual Diabetes Symposium,
Michigan Diabetes Research Center, Ann Arbor, MI
2015 “Response of human islets to insulin resistance and hyperglycemia,” Symposium at
Seoul International Congress of Endocrinology and Metabolism, Seoul, Korea
2015 “Pancreatic Islet and β cells: their Role in Type 1 and Type 2 Diabetes,” Plenary Lecture,
Seoul International Congress of Endocrinology and Metabolism, Seoul, Korea
2015 “Some Thoughts about β cells and Their Role in Type 1 and Type 2 Diabetes,” Keynote
Lecture, Joint Meeting of the Islet Study Group & Beta Cell Workshop, Jerusalem, Israel
2015 “Some Thoughts about β cells and Their Role in Type 1 Diabetes,” Diabetes Center 15th
Anniversary Symposium, University of California, San Francisco, San Francisco, CA
2015 "Interruption of hepatic glucagon signaling reveals liver-islet axis controlling alpha cell
proliferation," World Diabetes Congress. International Diabetes Federation, Vancouver,
Canada
2016 “Some Thoughts about β cells and Their Role in Type 1 Diabetes,” Endocrinology Grand
Rounds, University of Texas Southwestern Medical Center, Dallas, TX
2016 "Interruption of hepatic glucagon signaling reveals liver-islet axis controlling alpha cell
proliferation," Seminar in Obesity, Metabolism, and Diabetes, University of Texas
Southwestern Medical Center, Dallas, TX
2016 "Treatment of Type 1 Diabetes: Now and in the Future," Clinical Diabetes &
Endocrinology Conference, Snowmass, CO
2016 "Changes in Our Understanding of the Pathogenesis of Type 1 Diabetes," Clinical
Diabetes & Endocrinology Conference, Snowmass, CO
2016 "GLP-1-based Therapies for Diabetes," Clinical Diabetes & Endocrinology Conference,
Snowmass, CO
2016 "Approaches to Study β Cells, Pancreas, and Islets in Type 1 Diabetes," Satellite
Meeting of JDRF nPOD 8th Annual Scientific Meeting, Miami, FL
2016 "The influence of age on human pancreas development," JDRF nPOD 8th Annual
Scientific Meeting, Miami, FL
2016 "Interactions of Endothelial Cells, Macrophages, and Islet Cells," Keystone Symposia,
Islet Biology: From Cell Birth to Death, Keystone, CO
2016 “Some Thoughts about β Cells and Their Role in Type 1 Diabetes,” Lunenfeld-
Tanenbaum International Symposium: Translational Diabetes and Metabolism
Research 2016, Toronto, Canada
2016 “Role of β cells in Type 1 and Type 2 Diabetes,” Keynote speaker at 7
th
annual D-Cure
Symposium, Herzliya, Israel
Alvin Carter Powers, MD, Curriculum Vitae - Page 36
2016 “Changes in the Understanding of Pathogenesis of Type 1 Diabetes: Implications for
Prevention and Treatment,” Keynote Speaker at 31
st
Annual Clinical Conference on
Diabetes, American Diabetes Association, Jacksonville, FL
2016 “A Hepatic-Alpha Cell Axis,” European Association for the Study of Diabetes--Hagedorn
Oxford Workshop (Glucagon, the alpha-cell and intra-islet paracrine relationship),
Oxford, England
2016 “New Technologies to Sense Glucose and Replace Insulin,” Plenary speaker at
American Diabetes Association-Primer Academy of Medical Sciences, Clinical Update
in Diabetes, Bangalore, India
2016 “New Prospects and Challenges for Islet Transplantation,” American Diabetes
Association-Primer Academy of Medical Sciences, Clinical Update in Diabetes,
Bangalore, India
2016 “Insulin Innovations: Newer, Smarter, and Better?” American Diabetes Association-
Primer Academy of Medical Sciences, Clinical Update in Diabetes, Bangalore, India
2016 “Some Thoughts on β cells and Islets in Childhood,” American Diabetes Association-
Primer Academy of Medical Sciences, Changing Diabetes in Children, Bangalore, India
2016 “Changes in the Understanding of Pathogenesis of Type 1 Diabetes: Implications for
Prevention and Treatment,” Keynote Speaker at 35th Annual Conference on Diabetes,
American Diabetes Association, Hollywood, FL
2016 “Surprises and Unknowns in the Pancreas in Type 1 Diabetes,” Düsseldorf Diabetes
Lecture series, German Diabetes Center, Dusseldorf, Germany
2016 “Pushing the Boundaries of Knowledge to Advance Therapies for Type 1 Diabetes,”
Invited Panel Discussion, T1D Exchange Annual Meeting, Boston, MA
2016 “Diabetes and Chronic Kidney Disease – similar challenges,” Advances in Research
Conference, “Metabolic Phenotyping: From Mouse to Man,” Satellite meeting of
American Society of Nephrology annual meeting, Chicago, IL
2016 “Plasticity in the Young Human Pancreas,” University of Pennsylvania Institute of
Diabetes, Obesity, and Metabolism, Philadelphia, PA
2016 “Surprises and Unknowns in the Pancreas in Type 1 Diabetes,” Naomi Berrie Diabetes
Center, Columbia University, New York, NY
2017 “Changes in Our Understanding of the Pathogenesis of Type 1 Diabetes,” Julio V.
Santiago, M.D. Memorial Lecture, Department of Medicine Grand Rounds, Washington
University, St. Louis, MO
2017 “Pancreatogenic diabetes and multiple endocrine neoplasia,” Multiple Endocrine
Neoplasia Seminar for Patients, Families, and Providers, Vanderbilt University Medical
Center, Nashville, TN
2017 “Interrupted Glucagon Signaling Reveals Liver – Alpha Cell Axis,” 18th Servier-IGIS
Symposium, Nice, France
2017 “Changes in Our Understanding of the Pathogenesis of Type 1 Diabetes,” Department of
Medicine Grand Rounds, University of Colorado, Denver, CO
2017 “Diabetes: Plethora of Challenges for Society, Science, and Individuals,” University of
Massachusetts Medical School, Diabetes Center of Excellence, Diabetes Day Keynote
Address, Worcester, MA
2017 “Changes in Our Understanding of the Pathogenesis of Type 1 Diabetes,” James R.
Givens Distinguished Visiting Professor and Medical Grounds, Division of
Endocrinology, Diabetes & Metabolism in the Department of Medicine, University of
Tennessee Health Sciences Center, Memphis, TN
2017 “Diabetes: Challenges and Opportunities for Society, Science, and You (and the ADA),”
Presidential Address, 77th Annual Meeting of the American Diabetes Association, San
Diego, CA
Alvin Carter Powers, MD, Curriculum Vitae - Page 37
2017 “Past, Present and Future: The Affordable Care Act and Diabetes,” 77th Annual Meeting
of the American Diabetes Association, San Diego, CA
2017 “Changes in Our Understanding of Islet Cell Loss or Dysfunction in Type 1 Diabetes and
Type 2 Diabetes,” Plenary Address, 4th Annual Dr. Mohan’s International Diabetes
Update, Chennai, India
2017 “Current and emerging technologies to optimize insulin replacement,” 4th Annual Dr.
Mohan’s International Diabetes Update, Chennai, India
2017 “Organ Donation for Research: Providing New Insights into Diabetes,” Musculoskeletal
Transplant Foundation Leadership Summit, Park City, Utah
2017 Glucose Homeostasis: Integrated and Interrelated Systems of “Systems Biology”,
CeNSE Seminar, Indian Institute of Science, Bangalore, India
2017 “Islet Cell Loss or Dysfunction in Type 1 Diabetes and Type 2 Diabetes,” Plenary
Address, 3rd Annual American Diabetes Association-Academy of Medical Sciences
meeting, Bangalore, India
2017 “Current and emerging technologies to optimize insulin replacement,” 3rd Annual
American Diabetes Association-Academy of Medical Sciences meeting, Bangalore, India
2017 “Glucagon and alpha cell – more important in diabetes than we thought?” Plenary
Address, 3rd Annual American Diabetes Association-Academy of Medical Sciences
meeting, Bangalore, India
2017 “Pancreatic Islet Biology, Function, and Dysfunction: surprises and lessons for diabetes,”
Vanderbilt Diabetes Research and Training Center seminar series, Nashville, TN
2017 “Challenges (and Importance) for Integrating Rodent and Human Pancreas and
Pancreatic Islet Biology,” at Interface of Pancreatic Cancer with Diabetes, Obesity and
Inflammation: Research Gaps and Opportunities Workshop, sponsored by NIDDK,
Bethesda, MD
2017 “Pancreatic Islet Biology, Function, and Dysfunction: surprises and lessons for diabetes,”
Ray A. and Robert L. Kroc Lectureship in Diabetes and Endocrinology, Stanford
Diabetes Research Center, Stanford University, Paolo Alto, CA
2018 “Early Human Pancreatic Islet Development and Function,” Keystone Symposia,
Frontiers in Islet Biology and Diabetes, Keystone, CO
2018 “Diabetes Mellitus: Intersection of Health, Science, and Research,” Science National
Honors Society at Ravenwood High School, Brentwood, TN
2018 “Type 1 Diabetes; New Insights, New Therapies and New Challenges,” Harold Rifkin
Lectureship in Diabetes and Endocrinology, Medical Grand Rounds, Montefiore Medical
Center, Albert Einstein College of Medicine, New York, NY
2018 “Alpha Cells, Glucagon, and Diabetes: no longer an afterthought,” Research Seminar,
Albert Einstein College of Medicine, New York, NY
2018 “Multi-variable equations, dominos (not the pizza), and boats: some thoughts about
science and medicine,” invited Graduate Student Seminar, Department of Molecular
Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN
2018 “Understanding Human Disease: Challenges in Translation as Shown by Type 1
Diabetes,” Endocrine Grand Rounds, Mt. Sinai School of Medicine, New York, NY
2018 “Alpha Cells, Glucagon, and Diabetes: no longer an afterthought,” Work in Progress
Seminar Series, Icahn School of Medicine at Mount Sinai Obesity, Diabetes and
Metabolism Institute, New York, NY
2018 “Type 1 Diabetes; New Insights, New Therapies and New Challenges,” Keynote speaker
at JDRF 11th Annual Type One Nation Summit – Michigan/Ohio, Belleville, MI
2018 “Understanding Human Diabetes: Challenges in Translation as Shown by Type 1
Diabetes,” Plenary Speaker, 8th Annual Obesity and Diabetes Research Day,
Barnstable Brown Diabetes and Obesity Research Center, University of Kentucky,
Lexington, KY
Alvin Carter Powers, MD, Curriculum Vitae - Page 38
2018 “Type 1 Diabetes; New Insights, New Therapies and New Challenges,” Kenneth Crispell
Memorial Lectureship, Endocrine Grand Rounds, University of Virginia Medical Center,
Charlottesville, VA
2018 “Type 1 Diabetes; New Insights, New Therapies and New Challenges,” Kenneth Crispell
Memorial Lectureship, Medical Grand Rounds, University of Virginia Medical Center,
Charlottesville, VA
2018 “Insulin: Patient$, Doctor$, Insurer$, Manufacturer$, and $ociety,” Department of
Medicine, Medical Grand Rounds, Vanderbilt University Medical Center, Nashville, TN
2018 “Funding Opportunities” and “Keep Your Options Open,” Focus on Fellows Program at
78
th
Session of American Diabetes Association, Orlando, FL
2018 “Pancreatic Islet Biology, Function, and Dysfunction: Surprises and Lessons for
Diabetes,” Research Seminar, Helmholtz Diabetes Center, Garching, Germany
2018 “Diabetes in the ‘Elderly’ – many faces, challenges, and possibilities,” 4
th
Annual
Dimensions in Diabetes Symposium, organized by the Endocrine Society, Mumbai, India
2018 “Insulin: Patient$, Doctor$, Insurer$, Manufacturer$, and $ociety,” Clinical Endocrinology
Update, The Endocrine Society, Miami, FL
2018 “Insulin: Patient$, Doctor$, Insurer$, Manufacturer$, and $ociety,” Clinical Endocrinology
Update, The Endocrine Society, Anaheim, CA
2018 “Pancreas and Islet Biology: Three Snippets Related to Human Type 1 Diabetes,”
Clinical Endocrinology Update, Immunology of Diabetes Society, London, UK
2018 “Pancreas and Islet Biology: Stories Related to Human Diabetes,” 3rd Beta Cell Therapy
Symposium on Diabetes, Cleveland Clinic, Cleveland, OH
2019 “Pancreatic Islet Biology, Function, and Dysfunction: Surprises and Lessons for
Diabetes,” Department of Cellular and Physiology, University of British Columbia,
Vancouver, CA
2019 “Current Management of Type 2 Diabetes: Changing and Evolving,” Cardiology Update,
Vanderbilt University Medical Center, Nashville, TN
2019 “Alpha Cells, Glucagon, and Diabetes: no longer an afterthought,” Department of
Biochemistry Seminar, University of Wisconsin, Madison, WI
2019 “Pancreatic Islet Biology, Function, and Dysfunction: Surprises and Lessons for
Translational Research,” Keynote speaker, Diabetes Day, University of Wisconsin,
Madison, WI
2019 “Pancreatlas and Human Atlas of the Neonatal Development and Early Life – Pancreas
(Handel-P),” Annual Meeting of Network of Pancreatic Organ Donors with Diabetes
(nPOD), Ft Lauderdale, FL
2019 “Diabete$: Patient$, Doctor$, Insurer$, Manufacturer$, and $ociety,” Medical Grand
Rounds and Kroc Distinguished Visiting Professorship, Baylor College of Medicine,
Houston, TX
2019 “Pancreatic Islet Biology, Function, and Dysfunction: Surprises and Lessons for
Diabetes,” Endocrinology Grand Rounds and Kroc Distinguished Visiting Professorship,
Baylor College of Medicine, Houston, TX
2019 “Diabetes: Typical, Atypical, and Other Flavors,” Meet-the-Professor Session, Annual
Meeting of the Endocrine Society, New Orleans, LA
Patents:
1. U.S. patent # 5,821,334, 10/13/98, “Insulin-dependent Diabetes Mellitus-Specific Chimeric
Polypeptides”, Alvin C. Powers
2. U.S. patent # 5,968,757, 10/19/99, “Insulin-dependent Diabetes Mellitus-Specific Chimeric
Polypeptides”, Alvin C. Powers
Alvin Carter Powers, MD, Curriculum Vitae - Page 39
3. U.S. Patent, # 5,997,900, 12/7/99, “Encapsulation System for the Immunoisolation of Living
Cells”, Taylor G. Wang, Igor Lacik, Marcela Brissova, A. V. Anilkumar, Ales Prokop, Alvin C.
Powers
4. Patent pending (submitted 2018), Approaches to promote alpha islet cell expansion. Alvin C.
Powers, Danielle Dean
